Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O88621 Foxh1
| Class:Id | ReferenceGeneProduct:90713 |
|---|---|
| _chainChangeLog | chain:1-401 added on Fri February 6 2015 |
| _displayName | UniProt:O88621 Foxh1 |
| _timestamp | 2023-11-03 16:56:39 |
| chain | chain:1-401 |
| checksum | FB11DC9779DF1454 |
| comment | FUNCTION Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).SUBUNIT Interacts with the MH2 domains of SMAD2 and SMAD3.INTERACTION Expressed predominantly throughout the epiblast before gastrulation and declines as development progresses.DOMAIN The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity).MISCELLANEOUS Fails to bind DNA and cannot confer activin response element responsiveness. |
| description | recommendedName: Forkhead box protein H1 alternativeName: Forkhead activin signal transducer 1 shortName: Fast-1 alternativeName: Forkhead activin signal transducer 2 shortName: Fast-2 |
| geneName | Foxh1 Fast1 Fast2 |
| identifier | O88621 |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative splicing DNA-binding Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Foxh1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FOXH1_MOUSE Q9QZL5 Q9R241 |
| sequenceLength | 401 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:147543] UniProt:O88621-2 Foxh1 [Mus musculus] [ReferenceIsoform:401962] UniProt:O88621-1 Foxh1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:1225893] Foxh1 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O88621 Foxh1 (90713)
