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Details on Person UniProt:Q61850 Foxc2
| Class:Id | ReferenceGeneProduct:90700 |
|---|---|
| _chainChangeLog | chain:1-494 added on Fri February 6 2015 |
| _displayName | UniProt:Q61850 Foxc2 |
| _timestamp | 2024-02-26 04:44:28 |
| chain | chain:1-494 |
| checksum | 232C0D6FA64320A6 |
| comment | FUNCTION Transcriptional activator.SUBCELLULAR LOCATION Expressed in the brain, muscle, heart, fat, kidney, lung, liver, uterus, ovary and testis.DEVELOPMENTAL STAGE Expressed at 10.5 dpc to 18.5 dpc, expression peaks at 11.5 dpc and decreases thereafter (PubMed:8674414). Expressed in the non-notochordal mesoderm at 7.5 dpc (PubMed:8674414). Expressed in areas of mesenchymal condensation in the trunk, head and limbs at 8 dpc (PubMed:8674414). Widely expressed in mesenteric lymphatic endothelial cells at 16.5 dpc, expression thereafter is restricted to the lymphatic valve region at 18.5 dpc (at protein level) (PubMed:28179430). Also expressed in skin lymphatic endothelial cells at 15.5 and 18.5 dpc (PubMed:28179430).PTM Phosphorylation regulates FOXC2 transcriptional activity by promoting its recruitment to chromatin. |
| description | recommendedName: Forkhead box protein C2 alternativeName: Brain factor 3 shortName: BF-3 alternativeName: Forkhead-related protein FKHL14 alternativeName: Mesenchyme fork head protein 1 shortName: MFH-1 protein alternativeName: Transcription factor FKH-14 |
| geneName | Foxc2 Fkh14 Fkhl14 Mfh1 |
| identifier | Q61850 |
| isSequenceChanged | FALSE |
| keyword | Activator Developmental protein DNA-binding Isopeptide bond Methylation Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | Foxc2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FOXC2_MOUSE P97948 Q63869 Q8C694 |
| sequenceLength | 494 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:3927893] polySumo2,3-K213-Foxc2 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:3927958] Foxc2 [nucleoplasm] [Mus musculus] |
| (referenceSequence) | [GroupModifiedResidue:3927892] sumoylated lysine (polySumo2,3 [nucleoplasm]) at 213 |
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No pathways have been reviewed or authored by UniProt:Q61850 Foxc2 (90700)
