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Details on Person Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate

Class:Id	Reaction:904864
_displayName	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate
_doRelease	TRUE
_timestamp	2024-12-04 22:39:54
authored	[InstanceEdit:904848] D'Eustachio, P, 2010-07-05
catalystActivity	[CatalystActivity:904847] L-alanine:glyoxylate transaminase activity of AGXT2 tetramer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:904848] D'Eustachio, P, 2010-07-05
crossReference	[DatabaseIdentifier:9930605] RHEA:24249
edited	[InstanceEdit:904848] D'Eustachio, P, 2010-07-05
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
input	[SimpleEntity:379697] L-Ala [mitochondrial matrix] [SimpleEntity:904849] glyoxylate [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:904862] Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production [LiteratureReference:904851] Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver
modified	[InstanceEdit:904865] D'Eustachio, P, 2010-07-05 [InstanceEdit:904866] D'Eustachio, P, 2010-07-05 [InstanceEdit:1004535] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080820] D'Eustachio, P, 2010-11-27 [InstanceEdit:6784426] D'Eustachio, Peter, 2015-06-19 [InstanceEdit:6784529] D'Eustachio, Peter, 2015-06-20 [InstanceEdit:8949530] D'Eustachio, Peter, 2016-11-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
name	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate glyoxylate + L-alanine => glycine + pyruvate
output	[SimpleEntity:159549] Gly [mitochondrial matrix] [SimpleEntity:113557] PYR [mitochondrial matrix]
precedingEvent	[Reaction:6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate [Homo sapiens] [Reaction:6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104720] R-HSA-904864.5
summation	[Summation:904857] Mitochondrial AGXT2 (alanine-glyoxylate transaminase 2) cata...
(hasEvent)	[Pathway:389661] Glyoxylate metabolism and glycine degradation [Homo sapiens]
(precedingEvent)	[Reaction:5693967] PXLP-K754-GLDC dimer decarboxylates Gly [Homo sapiens]
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