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Details on Person UniProt:Q91XW8 Fkbp6
| Class:Id | ReferenceGeneProduct:90452 |
|---|---|
| _chainChangeLog | chain:1-327 added on Fri February 6 2015 |
| _displayName | UniProt:Q91XW8 Fkbp6 |
| _timestamp | 2023-11-03 15:02:16 |
| chain | chain:1-327 |
| checksum | 9A2AE310DDC064CD |
| comment | FUNCTION Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.SUBUNIT Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity (By similarity). Interacts (via TPR repeats) with HSP90.SUBCELLULAR LOCATION Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (synaptonemal complex).ALTERNATIVE PRODUCTS Testis-specific.DEVELOPMENTAL STAGE Present in spermatocytes. Expression is lost as cells exit prophase I. Not detected in spermatids (at protein level).DISRUPTION PHENOTYPE Males mice are sterile and aspermic due to abnormal pachytene spermatocytes, characterized by the appearance of unusual inclusion bodies and dense compacted nuclei. Spermatocytes fail to proceed beyond the pachytene stage due to abnormal pairing and misalignments between homologous chromosomes, non-homologous partner switches and autosynapsis of X chromosome cores in meiotic spermatocytes. No other abnormalities are detected in any tissues of males. Females mice are fertile (PubMed:12764197). Spermatocytes show derepressed LINE-1 retrotransposon and reduced DNA methylation due to deficient nuclear accumulation of Miwi2 (PubMed:22902560).SIMILARITY Belongs to the FKBP6 family.CAUTION Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity. |
| description | recommendedName: Inactive peptidyl-prolyl cis-trans isomerase FKBP6 shortName: Inactive PPIase FKBP6 alternativeName: 36 kDa FK506-binding protein shortName: 36 kDa FKBP shortName: FKBP-36 alternativeName: FK506-binding protein 6 shortName: FKBP-6 alternativeName: Immunophilin FKBP36 |
| geneName | Fkbp6 Fkbp36 |
| identifier | Q91XW8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Chromosome Cytoplasm Differentiation Meiosis Nucleus Reference proteome Repeat RNA-mediated gene silencing Spermatogenesis TPR repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Fkbp6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FKBP6_MOUSE Q8C1Y1 Q91VB7 Q91Y30 |
| sequenceLength | 327 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:147344] UniProt:Q91XW8-2 Fkbp6 [Mus musculus] [ReferenceIsoform:412304] UniProt:Q91XW8-1 Fkbp6 [Mus musculus] [ReferenceIsoform:8971433] UniProt:Q91XW8-3 Fkbp6 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:912425] Fkbp6 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:5605391] Fkbp6 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q91XW8 Fkbp6 (90452)
