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Details on Person UniProt:P07589 FN1
| Class:Id | ReferenceGeneProduct:90428 |
|---|---|
| _chainChangeLog | signal peptide:1-32 added on Fri February 6 2015;chain:33-2478 added on Fri February 6 2015;chain:628-702 added on Fri February 6 2015 |
| _displayName | UniProt:P07589 FN1 |
| _timestamp | 2024-02-26 04:37:33 |
| chain | signal peptide:1-32 chain:33-2478 chain:628-702 |
| checksum | 2BAD301A8112FEDC |
| comment | FUNCTION Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).FUNCTION Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.FUNCTION Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling.SUBUNIT Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts (via type III repeats 9-14) with TNFAIP6 (via CUB domain); this interaction enhances fibronectin fibril assembly. TNFAIP6 may act as a bridging molecule between FN1 and THBS1 (By similarity). Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3 and MYOC (By similarity). Interacts with SVEP1 (By similarity).INTERACTION A number of isoforms are produced. The diversity of isoforms depends on the V region and either of the two extra domain which can be either included or excluded (partially or completely for the V region).PTM Sulfated.PTM Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).PTM Proteolytic processing produces the C-terminal NC1 peptide, anastellin.PTM Some lysine residues are oxidized to allysine by LOXL3, promoting fibronectin activation and matrix formation.PTM Serotonylated on Gln residues by TGM2 in response to hypoxia. |
| description | recommendedName: fullName evidence="2"Fibronectin shortName: FN component recommendedName: Anastellin /component |
| geneName | FN1 |
| identifier | P07589 |
| isSequenceChanged | FALSE |
| keyword | Acute phase Alternative splicing Angiogenesis Cell adhesion Cell shape Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Heparin-binding Isopeptide bond Oxidation Phosphoprotein Pyrrolidone carboxylic acid Reference proteome Repeat Secreted Signal Sulfation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | FN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FINC_BOVIN |
| sequenceLength | 2478 |
| species | [Species:48898] Bos taurus |
| (isoformParent) | [ReferenceIsoform:402540] UniProt:P07589-1 FN1 [Bos taurus] |
| (referenceEntity) | [EntityWithAccessionedSequence:2533884] Fibronectin [extracellular region] [Bos taurus] [EntityWithAccessionedSequence:2533908] Fibronectin C-term fragment [extracellular region] [Bos taurus] [EntityWithAccessionedSequence:2533920] Fibronectin N-term fragment [extracellular region] [Bos taurus] |
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No pathways have been reviewed or authored by UniProt:P07589 FN1 (90428)
