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Details on Person TLR3 ligand [endosome lumen]

Class:Id	DefinedSet:9038432
_displayName	TLR3 ligand [endosome lumen]
_timestamp	2018-02-26 23:21:24
compartment	[Compartment:171907] endosome lumen
created	[InstanceEdit:9038433] Shamovsky, Veronica, 2018-02-26
disease	[Disease:3134794] viral infectious disease
hasMember	[GenomeEncodedEntity:8982440] Rotavirus dsRNA [endosome lumen] [Rotavirus] [GenomeEncodedEntity:6791257] HSV1 dsRNA intermediate form [endosome lumen] [Human herpesvirus 1] [GenomeEncodedEntity:8982462] HCV dsRNA intermediate form [endosome lumen] [Hepatitis C Virus] [GenomeEncodedEntity:8982481] HBV dsRNA intermediate form [endosome lumen] [Hepatitis B virus] [GenomeEncodedEntity:9028895] Influenza A dsRNA intermediate form [endosome lumen] [Influenza A virus]
literatureReference	[LiteratureReference:5602508] Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells [LiteratureReference:8982486] Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates [LiteratureReference:8982465] Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication [LiteratureReference:5602442] TLR3 deficiency in patients with herpes simplex encephalitis [LiteratureReference:8982450] Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells [LiteratureReference:8982482] HCV dsRNA-Activated Macrophages Inhibit HCV Replication in Hepatocytes [LiteratureReference:8982463] Association of Toll-like receptor 3 polymorphisms with chronic hepatitis B and hepatitis B-related acute-on-chronic liver failure [LiteratureReference:8982485] A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy [LiteratureReference:8982456] Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus [LiteratureReference:8982474] Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility
name	TLR3 ligand
species	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:9031716] Influenza A virus [Species:5617433] Rotavirus
stableIdentifier	[StableIdentifier:9038434] R-NUL-9038432.1
(hasComponent)	[Complex:167985] viral dsRNA :TLR3 [endosome membrane] [Homo sapiens]
(input)	[Reaction:168092] Viral dsRNA binds the Toll-Like Receptor 3 (TLR3) [Homo sapiens]
(replacementInstances)	[_Deleted:9038438] Deletion of instance: 8982478
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No pathways have been reviewed or authored by TLR3 ligand [endosome lumen] (9038432)