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Details on Person NLRP3 elicitor proteins [cytosol]

Class:Id	DefinedSet:9038383
_displayName	NLRP3 elicitor proteins [cytosol]
_timestamp	2020-08-19 16:28:33
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9038382] D'Eustachio, Peter, 2018-02-26
disease	[Disease:3134792] bacterial infectious disease
hasMember	[EntityWithAccessionedSequence:877217] Alpha-hemolysin [cytosol] [Staphylococcus aureus] [EntityWithAccessionedSequence:877188] APP(672-711) [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:877174] Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells [LiteratureReference:877204] NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury [LiteratureReference:877197] The Nalp3 inflammasome is essential for the development of silicosis [LiteratureReference:874004] The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
modified	[InstanceEdit:9038386] D'Eustachio, Peter, 2018-02-26 [InstanceEdit:9697673] Shamovsky, Veronica, 2020-08-19
name	NLRP3 elicitor proteins
species	[Species:48887] Homo sapiens [Species:877180] Staphylococcus aureus
stableIdentifier	[StableIdentifier:9038384] R-NUL-9038383.2
summation	[Summation:877202] Several intact viruses, fungi and bacteria can induce NLRP3 ...
(hasComponent)	[Complex:1306879] NLRP3 elicitor proteins:NLRP3 [cytosol] [Homo sapiens] [Complex:9794753] ITA-NLRP3:NLRP3 elicitor proteins [cytosol] [Homo sapiens] [Complex:9794858] NLRP3 elicitor proteins:oridonin-C279-NLRP3 [cytosol] [Homo sapiens]
(input)	[BlackBoxEvent:844440] NLRP3 activation by elicitor proteins [Homo sapiens]
(replacementInstances)	[_Deleted:9038385] Deletion of instance: 1306880
(updatedInstance)	[_UpdateTracker:9901490] Update Tracker - [DefinedSet:9038383] NLRP3 elicitor proteins [cytosol] - v74:[addDisease]
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No pathways have been reviewed or authored by NLRP3 elicitor proteins [cytosol] (9038383)