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Details on Person UniProt:Q6SW04 IRS1
| Class:Id | ReferenceGeneProduct:9037883 |
|---|---|
| _displayName | UniProt:Q6SW04 IRS1 |
| _timestamp | 2024-05-14 17:36:05 |
| chain | chain:1-847 |
| checksum | 2B699C571D00C980 |
| comment | FUNCTION Acts as a transactivator along with IE2, and is required for oriLyt-dependent DNA replication in the transient transfection replication assay using native promoters.SUBUNIT Interacts (via N-terminus) with the viral DNA polymerase accessory subunit UL44. Interacts (via C-terminus) with host EIF2AK2.SUBCELLULAR LOCATION Isoform IRS1-263 is predominantly nuclear.ALTERNATIVE PRODUCTS Belongs to the herpesviridae US22 family. |
| created | [InstanceEdit:9037922] Gillespie, Marc E, 2018-02-21 |
| description | recommendedName: Protein IRS1 |
| geneName | IRS1 |
| identifier | Q6SW04 |
| isSequenceChanged | FALSE |
| keyword | Alternative initiation Host cytoplasm Host nucleus Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Inhibition of host PKR by virus Interferon antiviral system evasion Reference proteome Transcription Viral immunoevasion Virion |
| modified | [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 |
| name | IRS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IRS1_HCMVM D2K3U7 |
| sequenceLength | 847 |
| species | [Species:2671791] Human cytomegalovirus |
| (isoformParent) | [ReferenceIsoform:9607535] UniProt:Q6SW04-1 IRS1 [Human cytomegalovirus] [ReferenceIsoform:9607536] UniProt:Q6SW04-2 IRS1 [Human cytomegalovirus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9605881] IRS1 [viral tegument] [Human cytomegalovirus] [EntityWithAccessionedSequence:9621064] IRS1 [cytosol] [Human cytomegalovirus] |
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No pathways have been reviewed or authored by UniProt:Q6SW04 IRS1 (9037883)
