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Details on Person As well as being a Golgi membrane resident, the histo-blood ...
| Class:Id | Summation:9037616 |
|---|---|
| _displayName | As well as being a Golgi membrane resident, the histo-blood ... |
| _timestamp | 2018-05-02 15:07:58 |
| created | [InstanceEdit:9037613] Jassal, Bijay, 2018-02-20 |
| modified | [InstanceEdit:9037621] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037624] Jassal, Bijay, 2018-02-20 [InstanceEdit:9607312] Jassal, Bijay, 2018-05-02 |
| text | As well as being a Golgi membrane resident, the histo-blood group ABO system transferase (ABO) can be proteolytically processed by an unknown protease into a soluble form, fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase (sABO). A, B and AB individuals express glycosyltransferase activities that convert the H antigen to the A antigen (by addition of GalNAc), to the B antigen (by addition of Gal) or to the AB antigen (by the addition of both GalNAc and Gal). O group individuals lack such activity. Differences in four critical amino acids (176, 235, 266 and 268) alter the specificity from an A to a B glycosyltransferase (Yamamoto et al. 1990, Yamamoto & McNeill 1996, Seto et al. 1999, Alfaro et al. 2008). The soluble form of histo-blood group A transferase (sABO-A) utilises UDP-GalNAc to transfer N-acetylgalactosamine (GalNAc) to the H antigen formed via Type 1 chains to form the A antigen in secretors (A antigen-sec) (Patenaude et al. 2002, Persson et al. 2007). |
| (summation) | [Reaction:9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec [Homo sapiens] |
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No pathways have been reviewed or authored by As well as being a Golgi membrane resident, the histo-blood ... (9037616)
