Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The H antigen is formed with the addition of a fucose (Fuc) ...
| Class:Id | Summation:9037569 |
|---|---|
| _displayName | The H antigen is formed with the addition of a fucose (Fuc) ... |
| _timestamp | 2018-05-02 15:08:10 |
| created | [InstanceEdit:9037568] Jassal, Bijay, 2018-02-19 |
| modified | [InstanceEdit:9037571] Jassal, Bijay, 2018-02-19 [InstanceEdit:9037572] Jassal, Bijay, 2018-02-19 [InstanceEdit:9605616] Jassal, Bijay, 2018-04-16 [InstanceEdit:9607312] Jassal, Bijay, 2018-05-02 |
| text | The H antigen is formed with the addition of a fucose (Fuc) sugar onto one of two precursor oligosaccharide sequences, Type 1 (RBCs) or Type 2 (secreted) chains. The FUT1 gene (aka H gene) found in hematopoietic cells produces galactoside 2-α-L-fucosyltransferase 1 (FUT1 aka α-1,2-fucosyltransferase 1) which mediates the transfer of a fucose (Fuc) sugar to the galactose (Gal) sugar of the Type 2 chain precursor Gal-β1,4-GlcNAc-β1,3-Gal-R (where R is a glycosphingolipid) to form the H antigen (Larsen et al. 1990). This is an essential step for subsequent formation of A and B antigens. Mutations that inactivate the FUT1 gene can result in the 'Bombay phenotype' where no A, B or H antigens are produced on RBCs (Koda et al 1997, Kaneko et al. 1997). |
| (summation) | [Reaction:9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The H antigen is formed with the addition of a fucose (Fuc) ... (9037569)
