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Details on Person Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3)...

Class:Id	Summation:9036971
_displayName	Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3)...
_timestamp	2018-03-26 23:46:53
created	[InstanceEdit:9036969] Orlic-Milacic, Marija, 2018-02-14
literatureReference	[LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events [LiteratureReference:9034894] Analysis of mitogen-activated protein kinase activation by naturally occurring splice variants of TrkC, the receptor for neurotrophin-3 [LiteratureReference:9026960] Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons
modified	[InstanceEdit:9603894] Orlic-Milacic, Marija, 2018-03-26
text	Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3) increases the amount of GTP-bound RAS (Marsh and Palfrey 1996). Activation of RAS targets MAPK3 (ERK1) and MAPK1 (ERK2) was shown to depend on SHC1-mediated recruitment of GRB2 to activated NTRK3 (Gunn-Moore et al. 1997, Yuen and Mobley 1999).
(summation)	[BlackBoxEvent:9036970] NTRK3 activates RAS through SHC1 [Homo sapiens]
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