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Details on Person NTRK3 activates RAS through SHC1

Class:Id	BlackBoxEvent:9036970
_displayName	NTRK3 activates RAS through SHC1
_doRelease	TRUE
_timestamp	2018-08-15 18:12:30
authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9036969] Orlic-Milacic, Marija, 2018-02-14
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
inferredFrom	[BlackBoxEvent:9616949] Ntrk3 activates Ras [Rattus norvegicus]
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:9036979] Orlic-Milacic, Marija, 2018-02-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9608099] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608102] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608366] Orlic-Milacic, Marija, 2018-05-14 [InstanceEdit:9616950] Orlic-Milacic, Marija, 2018-08-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK3 activates RAS through SHC1
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[BlackBoxEvent:9036949] NTRK3 binds GRB2:SOS1 through SHC1 [Homo sapiens] [Reaction:9034875] NTRK3 phosphorylates SHC1 [Homo sapiens]
regulatedBy	[PositiveRegulation:9036972] Positive regulation by 'NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane]'
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9036975] R-HSA-9036970.3
summation	[Summation:9036971] Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3)...
(hasEvent)	[Pathway:9034864] Activated NTRK3 signals through RAS [Homo sapiens]
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No pathways have been reviewed or authored by NTRK3 activates RAS through SHC1 (9036970)