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Details on Person GAA hydrolyzes lysosomal glycogen

Class:Id	Reaction:9036727
_displayName	GAA hydrolyzes lysosomal glycogen
_doRelease	TRUE
_timestamp	2018-02-07 21:03:45
authored	[InstanceEdit:5357603] D'Eustachio, Peter, 2014-03-24
catalystActivity	[CatalystActivity:5357535] alpha-glucosidase activity of GAA (70, 76 kDa) [lysosomal lumen]
catalystActivityReference	[CatalystActivityReference:9643896] alpha-glucosidase activity of GAA (70, 76 kDa) [lysosomal lumen] Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9036730] D'Eustachio, Peter, 2018-02-07
edited	[InstanceEdit:5357603] D'Eustachio, Peter, 2014-03-24
input	[Complex:9036726] glycogen-GYG1 dimer [lysosomal lumen] [Homo sapiens] [SimpleEntity:1605715] H2O [lysosomal lumen] [SimpleEntity:1605715] H2O [lysosomal lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:5357552] Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease [LiteratureReference:5357537] Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex [LiteratureReference:5357581] Specific functions of lysosomal proteases in endocytic and autophagic pathways [LiteratureReference:5357559] Structural and functional changes of lysosomal acid alpha-glucosidase during intracellular transport and maturation
modified	[InstanceEdit:9036735] D'Eustachio, Peter, 2018-02-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GAA hydrolyzes lysosomal glycogen GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen
output	[Complex:5357533] poly((1,4)-alpha-glucosyl)GYG1 dimer [lysosomal lumen] [Homo sapiens] [SimpleEntity:1605745] Glc [lysosomal lumen] [SimpleEntity:1605745] Glc [lysosomal lumen]
releaseDate	2015-03-19
reviewed	[InstanceEdit:5358504] Jassal, Bijay, 2014-03-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9036731] R-HSA-9036727.3
summation	[Summation:5357587] While most glycogen is cytosolic, glycogen granules are also...
(hasEvent)	[Pathway:70221] Glycogen breakdown (glycogenolysis) [Homo sapiens]
(normalReaction)	[FailedReaction:9036729] Defective GAA does not hydrolyze lysosomal glycogen [Homo sapiens]
(replacementInstances)	[_Deleted:9036737] Deletion of instances: 5357589, 5357585, 5357572
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