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Details on Person The ATP1B1 gene is transcribed to yield mRNA and the mRNA is...
| Class:Id | Summation:9036678 |
|---|---|
| _displayName | The ATP1B1 gene is transcribed to yield mRNA and the mRNA is... |
| _timestamp | 2018-02-08 02:17:51 |
| created | [InstanceEdit:9036644] Shamovsky, Veronica, 2018-02-06 |
| literatureReference | [LiteratureReference:9036712] Aldosterone increases Na+ -K+ -ATPase activity in skeletal muscle of patients with Conn's syndrome [LiteratureReference:9036677] Transcriptional regulation of the human Na/K ATPase via the human mineralocorticoid receptor [LiteratureReference:9036686] Transcriptional regulators of Na,K-ATPase subunits [LiteratureReference:9036665] Regulation of the human Na/K-ATPase beta1 gene promoter by mineralocorticoid and glucocorticoid receptors |
| modified | [InstanceEdit:9036707] Shamovsky, Veronica, 2018-02-06 [InstanceEdit:9036763] Shamovsky, Veronica, 2018-02-08 |
| text | The ATP1B1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. ATP1B1 gene encodes the sodium–potassium ATPase (Na,K-ATPase) β1-subunit. Aldosterone increased ATP1B1 transcripts in mammalian kidney, heart and vascular muscles (reviewed by Li Z & Langhans SA 2015). In addition, aldosterone was shown to regulate ATP1B1 expression through mineralocorticoid receptor (NR3C2 or MR) in human embryonic kidney HEK293, human pre-B leukemia 697, human colonic adenocarcinoma T84 cells and in human skeletal muscle (Kolla V & Litwack G 2000; Phakdeekitcharoen B et al. 2011). Human NR3C2 and glucocorticoid receptor (NR3C1) formed functional homo- and heterodimers that directly interacted with the GRE/MRE (−650 to −630 bp) in the regulatory region of ATB1B1 gene when the receptors were expressed in corticoids-treated monkey kidney epithelial COS-1 cells (Derfoul A et al. 1998). While NR3C2 or NR3C1 homodimers induced, their heterodimers effectively down-regulated the activation of the transcription from a promoter of ATP1B1 (Derfoul A et al. 1998). |
| (summation) | [BlackBoxEvent:9036638] Expression of ATP1B1 regulated by NR3C2 [Homo sapiens] |
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No pathways have been reviewed or authored by The ATP1B1 gene is transcribed to yield mRNA and the mRNA is... (9036678)
