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Details on Person Mineralocorticoids, like aldosterone, control Na+ reabsorpti...

Class:IdSummation:9036661
_displayNameMineralocorticoids, like aldosterone, control Na+ reabsorpti...
_timestamp2019-02-08 01:56:00
created[InstanceEdit:9036644] Shamovsky, Veronica, 2018-02-06
literatureReference[LiteratureReference:9036635] Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor
[LiteratureReference:9036685] Identification of a mineralocorticoid/glucocorticoid response element in the human Na/K ATPase alpha1 gene promoter
[LiteratureReference:9036677] Transcriptional regulation of the human Na/K ATPase via the human mineralocorticoid receptor
[LiteratureReference:9036669] Structural determinants of a glucocorticoid receptor recognition element
modified[InstanceEdit:9635716] Shamovsky, Veronica, 2019-02-08
textMineralocorticoids, like aldosterone, control Na+ reabsorption by regulating the mRNA level of the sodium–potassium ATPase (Na,K-ATPase) α1-subunit which is encoded by the gene ATP1A1 (Kolla V et al. 1999; Kolla V & Litwack G 2000; Salyer SA et al. 2013). In human kidney proximal tubule (HKC11) cells, treatment with aldosterone increased Na,K- ATPase-mediated (86) Rb uptake and expression of ATP1A1 (Salyer SA et al. 2013). The effect of aldosterone on Na,K- ATPase-mediated (86)Rb uptake was prevented by spironolactone, an antagonist of the mineralocorticoid receptor (NR3C2, MR), suggesting that the regulation occurs through an NR3C2-dependent mechanism (Salyer SA et al. 2013). Along with that, aldosterone regulated the expression of the Na/K ATPase alpha1 (ATP1A1) and beta1 (ATP1B1) subunits via the involvement of the NR3C2 (MR) in human embryonic kidney HEK293, pre-B leukemia 697 and colonic adenocarcinoma T84 cells (Kolla V & Litwack G 2000). Moreover, the ATP1A1 promoter was shown to contain two mineralocorticoid/glucocorticoid response element (MRE/GRE) sites (-598 to -574 bp and a half binding site at -246 bp) (Kolla V et al. 1999). The GRE is composed of imperfect inverted hexanucleotide repeats separated by three nucleotides GGTACA NNN TGTTCT (Nordeen SK et al. 1990). The mineralocorticoid receptor (NR3C2, MR) and the glucocorticoid receptor (NR3C1, GR) have been shown to bind the GRE in the regulatory region of the ATP1A1 gene (Kolla V et al. 1999).
(summation)[Reaction:9036653] NR3C2 binds the ATP1A1 gene [Homo sapiens]
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