Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of NR1H2 and NR1H3-mediated signaling

Class:IdPathwayDiagram:9035469
_displayNameDiagram of NR1H2 and NR1H3-mediated signaling
_timestamp2019-08-13 17:28:59
created[InstanceEdit:9035468] Shamovsky, Veronica, 2018-01-22
height2605
modified[InstanceEdit:9038336] Weiser, JD
[InstanceEdit:9605075] Shamovsky, Veronica, 2018-04-06
[InstanceEdit:9623448] Shamovsky, Veronica, 2018-10-04
[InstanceEdit:9624593] Shamovsky, Veronica, 2018-10-12
[InstanceEdit:9629141] Shamovsky, Veronica, 2018-11-19
[InstanceEdit:9631298] Shamovsky, Veronica, 2018-12-06
[InstanceEdit:9632481] Shamovsky, Veronica, 2018-12-18
[InstanceEdit:9632753] Shamovsky, Veronica, 2018-12-21
[InstanceEdit:9634160] Shamovsky, Veronica, 2019-01-07
[InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09
[InstanceEdit:9658262] Shamovsky, Veronica, 2019-08-12
[InstanceEdit:9658419] Shamovsky, Veronica, 2019-08-13
representedPathway[Pathway:9024446] NR1H2 and NR1H3-mediated signaling [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="1540" reactomeDiagramId="9035469"> <Properties> <displayName>Diagram of NR1H2 and NR1H3-mediated signaling</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="5" reactomeId="7660" position="882 1409" bounds="80 254 1604 2311" textPosition="152 266" bgColor="250 240 240" lineColor="255 153 102" insets="97 263 1576 2290"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="11" /> <Component id="16" /> <Component id="17" /> <Component id="12" /> <Component id="14" /> <Component id="18" /> <Component id="19" /> <Component id="20" /> <Component id="28" /> <Component id="30" /> <Component id="31" /> <Component id="32" /> <Component id="33" /> <Component id="44" /> <Component id="45" /> <Component id="46" /> <Component id="47" /> <Component id="53" /> <Component id="57" /> <Component id="58" /> <Component id="56" /> <Component id="63" /> <Component id="65" /> <Component id="66" /> <Component id="67" /> <Component id="76" /> <Component id="88" /> <Component id="89" /> <Component id="90" /> <Component id="95" /> <Component id="98" /> <Component id="99" /> <Component id="100" /> <Component id="102" /> <Component id="104" /> <Component id="103" /> <Component id="109" /> <Component id="111" /> <Component id="112" /> <Component id="113" /> <Component id="127" /> <Component id="128" /> <Component id="129" /> <Component id="130" /> <Component id="132" /> <Component id="133" /> <Component id="134" /> <Component id="140" /> <Component id="141" /> <Component id="154" /> <Component id="166" /> <Component id="167" /> <Component id="168" /> <Component id="97" /> <Component id="179" /> <Component id="180" /> <Component id="181" /> <Component id="230" /> <Component id="231" /> <Component id="232" /> <Component id="233" /> <Component id="234" /> <Component id="280" /> <Component id="325" /> <Component id="326" /> <Component id="540" /> <Component id="611" /> <Component id="15" /> <Component id="21" /> <Component id="13" /> <Component id="316" /> <Component id="235" /> <Component id="22" /> <Component id="23" /> <Component id="29" /> <Component id="648" /> <Component id="661" /> <Component id="664" /> <Component id="665" /> <Component id="541" /> <Component id="1293" /> <Component id="1294" /> <Component id="1295" /> <Component id="1345" /> <Component id="1356" /> <Component id="1357" /> <Component id="1358" /> <Component id="1359" /> <Component id="1363" /> <Component id="1362" /> <Component id="1361" /> <Component id="1366" /> <Component id="1374" /> <Component id="1375" /> <Component id="1373" /> <Component id="1376" /> <Component id="153" /> <Component id="142" /> <Component id="155" /> <Component id="139" /> <Component id="659" /> <Component id="1381" /> <Component id="1382" /> <Component id="1385" /> <Component id="1398" /> <Component id="1430" /> <Component id="1429" /> <Component id="1446" /> <Component id="1445" /> <Component id="1447" /> <Component id="1448" /> <Component id="1533" /> <Component id="1534" /> <Component id="1532" /> <Component id="1535" /> <Component id="1538" /> <Component id="1537" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="12" reactomeId="9024355" position="1538 616" bounds="1497 591 82 51" textPosition="1498 618"> <Properties> <displayName>ABCG1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="13" reactomeId="351642" position="1098 604" bounds="1079 593 39 22" textPosition="1079 593"> <Properties> <displayName>GPS2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="14" reactomeId="9024381" position="905 887" bounds="862 876 87 22" textPosition="872 870"> <Properties> <displayName>NR1H2,3:RXR</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="15" reactomeId="9024383" position="293 781" bounds="243 763 101 36" textPosition="242 763"> <Properties> <displayName>NR1H3, NR1H2 ligands</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="16" reactomeId="9024371" position="1129 518" bounds="1076 500 106 36" textPosition="1075 500"> <Properties> <displayName>KDM1A, KDM1B, KDM3A, KDM4A</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="17" reactomeId="9024378" position="1332 549" bounds="1267 524 130 50" textPosition="1267 525" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCG1 gene:NR1H2,3:RXR:oxysterol:GPS2:KDMs</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="19" reactomeId="9024349" position="540 332" bounds="477 307 126 50" textPosition="477 308" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="20" reactomeId="9024368" position="764 402" bounds="701 370 127 64" textPosition="702 371" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="22" reactomeId="9024373" position="908 462" bounds="852 444 113 36" textPosition="852 445" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NCOR:GPS2:TBL1:HDAC3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="23" reactomeId="9024330" position="994 398" bounds="931 373 127 50" textPosition="932 374" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="29" reactomeId="442496" position="1061 349" bounds="1035 338 53 22" textPosition="1036 338"> <Properties> <displayName>NCOA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="30" reactomeId="9029599" position="1223 401" bounds="1162 376 122 50" textPosition="1164 377" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="32" reactomeId="381325" position="1291 355" bounds="1269 344 45 22" textPosition="1272 338"> <Properties> <displayName>EP300</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="33" reactomeId="9029520" position="1442 397" bounds="1378 365 129 64" textPosition="1390 366" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="45" reactomeId="9029559" position="1525 724" bounds="1484 699 82 51" textPosition="1485 726"> <Properties> <displayName>ABCG5 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="46" reactomeId="9029543" position="1335 660" bounds="1269 635 132 50" textPosition="1282 636" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:ABCG5 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="48" reactomeId="265448" position="2043 703" bounds="2018 692 50 22" textPosition="2019 692"> <Properties> <displayName>ABCG5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="54" reactomeId="2975951" position="2049 595" bounds="2024 584 50 22" textPosition="2025 584"> <Properties> <displayName>ABCG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="57" reactomeId="9029518" position="1528 829" bounds="1487 804 82 51" textPosition="1488 831"> <Properties> <displayName>ABCG8 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="58" reactomeId="9029595" position="1333 767" bounds="1267 742 132 50" textPosition="1280 743" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:ABCG8 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="64" reactomeId="265487" position="2052 806" bounds="2027 795 50 22" textPosition="2028 795"> <Properties> <displayName>ABCG8</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="66" reactomeId="9035188" position="1528 926" bounds="1493 901 71 51" textPosition="1493 928"> <Properties> <displayName>CETP gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="67" reactomeId="9035197" position="1336 871" bounds="1270 846 132 50" textPosition="1283 847" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:CETP gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="77" reactomeId="194231" position="2104 904" bounds="2085 893 38 22" textPosition="2085 893"> <Properties> <displayName>CETP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="89" reactomeId="8869591" position="1492 1268" bounds="1456 1243 73 51" textPosition="1457 1270"> <Properties> <displayName>APOE gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="90" reactomeId="9031524" position="1354 1211" bounds="1288 1186 132 50" textPosition="1301 1187" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:APOE gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="96" reactomeId="174646" position="2124 1247" bounds="2104 1236 41 22" textPosition="2105 1236"> <Properties> <displayName>APOE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="98" reactomeId="9031516" position="1502 1373" bounds="1461 1348 83 51" textPosition="1462 1375"> <Properties> <displayName>APOC1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="99" reactomeId="9031523" position="1371 1310" bounds="1305 1285 132 50" textPosition="1318 1286" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:APOC1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="101" reactomeId="8855541" position="2114 1342" bounds="2089 1331 51 22" textPosition="2090 1331"> <Properties> <displayName>APOC1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="103" reactomeId="6784670" position="1503 1467" bounds="1462 1442 83 51" textPosition="1463 1469"> <Properties> <displayName>APOC2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="104" reactomeId="9031517" position="1344 1403" bounds="1278 1378 132 50" textPosition="1291 1379" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:APOC2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="110" reactomeId="174699" position="2111 1437" bounds="2086 1426 51 22" textPosition="2087 1426"> <Properties> <displayName>APOC2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="112" reactomeId="9035181" position="1515 1550" bounds="1474 1525 83 51" textPosition="1475 1552"> <Properties> <displayName>APOC4 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="113" reactomeId="9035153" position="1298 1487" bounds="1232 1462 132 50" textPosition="1245 1463" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:APOC4 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="128" reactomeId="9035145" position="1525 1769" bounds="1487 1744 77 51" textPosition="1500 1771"> <Properties> <displayName>EEPD1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="129" reactomeId="9035164" position="1182 1707" bounds="1116 1682 132 50" textPosition="1129 1683" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:EEPD1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="131" reactomeId="9035163" position="2050 1747" bounds="2028 1736 45 22" textPosition="2031 1730"> <Properties> <displayName>EEPD1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="133" reactomeId="9035162" position="1475 1162" bounds="1434 1137 82 51" textPosition="1434 1164"> <Properties> <displayName>NR1H3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="134" reactomeId="9035175" position="1373 1114" bounds="1318 1096 111 36" textPosition="1329 1083" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H3 gene:LXR:RXR:LXR ligands</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="140" reactomeId="2393979" position="1527 1954" bounds="1491 1929 72 51" textPosition="1492 1956"> <Properties> <displayName>FASN gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="141" reactomeId="4086031" position="529 2049" bounds="508 2038 43 22" textPosition="508 2038"> <Properties> <displayName>NRIP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="142" reactomeId="9028534" position="1115 1883" bounds="1051 1858 129 50" textPosition="1061 1859" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:FASN gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="148" reactomeId="199233" position="1757 1933" bounds="1737 1922 40 22" textPosition="1738 1922"> <Properties> <displayName>FASN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="154" reactomeId="6800051" position="1529 2036" bounds="1497 2011 65 51" textPosition="1498 2038"> <Properties> <displayName>SCD gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="155" reactomeId="9028535" position="1060 1970" bounds="994 1945 132 50" textPosition="1007 1946" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SCD gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="157" reactomeId="400117" position="1840 2015" bounds="1824 2004 33 22" textPosition="1825 2004"> <Properties> <displayName>SCD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="167" reactomeId="5641206" position="1536 2137" bounds="1495 2112 83 51" textPosition="1495 2139"> <Properties> <displayName>SREBF1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="168" reactomeId="9028528" position="1031 2079" bounds="967 2054 129 50" textPosition="971 2055" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SREBF1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="180" reactomeId="5640206" position="1548 2223" bounds="1512 2198 72 51" textPosition="1512 2225"> <Properties> <displayName>PCK1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="181" reactomeId="9028527" position="1032 2172" bounds="970 2154 124 36" textPosition="968 2141" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NRIP1:NR1H3:RXR:NR1H3 ligand:PCK1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="183" reactomeId="70495" position="1770 2201" bounds="1750 2190 40 22" textPosition="1750 2190"> <Properties> <displayName>PCK1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="231" reactomeId="9029554" position="198 2494" bounds="135 2476 127 36" textPosition="151 2463" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UGT1A3 gene:NR1H2,3:RXR:NCOR</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="232" reactomeId="9029556" position="447 2497" bounds="383 2465 129 64" textPosition="395 2466" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="234" reactomeId="349716" position="570 2442" bounds="519 2431 102 22" textPosition="520 2431"> <Properties> <displayName>NCOR1, NCOR2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="280" reactomeId="9035263" position="657 2497" bounds="594 2472 127 50" textPosition="607 2473" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="316" reactomeId="9035268" position="1109 2504" bounds="1045 2472 129 64" textPosition="1057 2473" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="326" reactomeId="9029598" position="1555 2520" bounds="1510 2495 91 51" textPosition="1511 2522"> <Properties> <displayName>UGT1A3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="327" reactomeId="174928" position="1905 2215" bounds="1876 2204 59 22" textPosition="1877 2204"> <Properties> <displayName>UGT1A3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="342" reactomeId="194209" position="2046 442" bounds="2021 431 50 22" textPosition="2022 431"> <Properties> <displayName>ABCA1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="541" reactomeId="8854957" position="1623 1077" bounds="1598 1066 50 22" textPosition="1598 1066"> <Properties> <displayName>NR1H3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="612" reactomeId="5215930" position="2113 1523" bounds="2088 1512 51 22" textPosition="2089 1512"> <Properties> <displayName>APOC4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="638" reactomeId="70101" position="1042 1404" bounds="27 211 2030 2386" textPosition="1121 1311" bgColor="250 240 240" lineColor="255 153 102" insets="41 226 1999 2354"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="342" /> <Component id="148" /> <Component id="639" /> <Component id="131" /> <Component id="183" /> <Component id="54" /> <Component id="48" /> <Component id="64" /> <Component id="649" /> <Component id="655" /> <Component id="657" /> <Component id="656" /> <Component id="727" /> <Component id="735" /> <Component id="5" /> <Component id="733" /> <Component id="734" /> <Component id="1346" /> <Component id="1347" /> <Component id="1349" /> <Component id="1348" /> <Component id="1350" /> <Component id="1351" /> <Component id="1360" /> <Component id="1380" /> <Component id="1386" /> <Component id="1431" /> <Component id="1432" /> <Component id="1434" /> <Component id="1433" /> <Component id="1438" /> <Component id="1436" /> <Component id="1440" /> <Component id="1439" /> <Component id="1441" /> <Component id="1442" /> <Component id="1443" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="639" reactomeId="17957" position="1915 2074" bounds="1847 1922 137 304" textPosition="1857 1951" bgColor="250 240 240" lineColor="255 153 102" insets="1854 1932 121 283"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="157" /> <Component id="327" /> <Component id="1399" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="648" reactomeId="442496" position="802 2465" bounds="776 2454 53 22" textPosition="777 2454" /> <org.gk.render.RenderableRNA id="649" reactomeId="9038553" position="1766 1141" bounds="1705 1122 122 38" textPosition="1721 1130"> <Properties> <displayName>NR1H3 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableEntitySet id="656" reactomeId="9038541" position="1817 1194" bounds="1772 1183 91 22" textPosition="1772 1183"> <Properties> <displayName>miR-613 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="657" reactomeId="9038554" position="1956 1161" bounds="1895 1143 122 36" textPosition="1909 1144" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H3 mRNA:miR-613 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="734" reactomeId="9619754" position="1937 495" bounds="1895 484 85 22" textPosition="1910 471" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2:RXRA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="735" reactomeId="9619752" position="2039 552" bounds="1974 541 130 22" textPosition="1974 542" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2:RXRA:ABCA1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="1294" reactomeId="9618395" position="1529 1863" bounds="1489 1838 81 51" textPosition="1490 1865"> <Properties> <displayName>ARL4C gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1295" reactomeId="9618399" position="1282 1805" bounds="1216 1780 132 50" textPosition="1229 1781" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:ARL4C gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="1346" reactomeId="9618397" position="1779 1824" bounds="1719 1805 121 38" textPosition="1736 1813"> <Properties> <displayName>ARL4C mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="1348" reactomeId="9618406" position="1950 1825" bounds="1926 1814 49 22" textPosition="1927 1814"> <Properties> <displayName>ARL4C</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1349" reactomeId="9618401" position="1888 1868" bounds="1828 1850 121 36" textPosition="1829 1851" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ARL4C mRNA:miR-26 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1351" reactomeId="9011867" position="1735 1877" bounds="1694 1866 83 22" textPosition="1694 1866"> <Properties> <displayName>miR-26 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1357" reactomeId="9623371" position="1509 1622" bounds="1472 1597 75 51" textPosition="1473 1624"> <Properties> <displayName>MYLIP gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1358" reactomeId="9623370" position="1328 1564" bounds="1262 1539 132 50" textPosition="1275 1540" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:MYLIP gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1360" reactomeId="8850908" position="1759 1596" bounds="1738 1585 43 22" textPosition="1739 1585"> <Properties> <displayName>MYLIP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1362" reactomeId="9624350" position="1542 1017" bounds="1508 992 69 51" textPosition="1508 1019"> <Properties> <displayName>PLTP gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1363" reactomeId="9624347" position="1339 962" bounds="1272 937 135 50" textPosition="1271 938" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:PLTP gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1367" reactomeId="194227" position="2101 997" bounds="2083 986 36 22" textPosition="2083 986"> <Properties> <displayName>PLTP</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1374" reactomeId="5640178" position="1558 2308" bounds="1517 2283 82 51" textPosition="1521 2310"> <Properties> <displayName>PLIN1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1375" reactomeId="9608036" position="990 2248" bounds="934 2223 112 50" textPosition="939 2224" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PLIN1 gene:NR1H2,3:RXR:NR1H2,3 ligand</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1377" reactomeId="163460" position="1728 2321" bounds="1706 2310 45 22" textPosition="1708 2310"> <Properties> <displayName>PLIN1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="1380" reactomeId="13977" position="1789 2304" bounds="1727 2246 124 116" textPosition="1740 2273" bgColor="250 240 240" lineColor="255 153 102" insets="1737 2254 104 100"> <Properties> <displayName>lipid droplet</displayName> </Properties> <Components> <Component id="1377" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="1382" reactomeId="9607340" position="1553 2382" bounds="1513 2357 80 51" textPosition="1515 2384"> <Properties> <displayName>FABP6 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="1386" reactomeId="194158" position="1737 2395" bounds="1715 2384 45 22" textPosition="1715 2384"> <Properties> <displayName>FABP6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1398" reactomeId="9631294" position="1003 2321" bounds="950 2296 107 50" textPosition="951 2297" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:FABP6 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1399" reactomeId="1655761" position="1854 2113" bounds="1821 2102 66 22" textPosition="1821 2102"> <Properties> <displayName>SREBF1-3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1430" reactomeId="5649950" position="1533 465" bounds="1503 440 61 51" textPosition="1508 467"> <Properties> <displayName>ABCA1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="1431" reactomeId="9618483" position="1750 442" bounds="1701 423 99 38" textPosition="1707 431"> <Properties> <displayName>ABCA1 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="1433" reactomeId="9624931" position="1877 365" bounds="1820 347 114 36" textPosition="1831 348" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCA1 mRNA:miR-33 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1434" reactomeId="9618481" position="1930 323" bounds="1873 305 114 36" textPosition="1884 306" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCA1 mRNA:miR-26 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1438" reactomeId="9011867" position="1738 286" bounds="1697 275 83 22" textPosition="1697 275" /> <org.gk.render.RenderableEntitySet id="1440" reactomeId="9624917" position="1729 329" bounds="1693 318 72 22" textPosition="1700 312"> <Properties> <displayName>miR-33 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="1441" reactomeId="9657867" position="1961 272" bounds="1901 254 121 36" textPosition="1901 255" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ABCA1 mRNA:miR-144 RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1443" reactomeId="9657800" position="1742 248" bounds="1690 237 104 22" textPosition="1697 237"> <Properties> <displayName>miR-144 RISC</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="1446" reactomeId="9657823" position="1532 1684" bounds="1487 1659 90 51" textPosition="1495 1686"> <Properties> <displayName>APOD gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1447" reactomeId="9657777" position="1329 1631" bounds="1270 1606 119 50" textPosition="1277 1607" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:APOD gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1449" reactomeId="5216199" position="2115 1657" bounds="2089 1646 53 22" textPosition="2095 1646"> <Properties> <displayName>APOD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="1533" reactomeId="9657846" position="1547 2442" bounds="1499 2417 97 51" textPosition="1500 2444"> <Properties> <displayName>ANGPTL3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="1534" reactomeId="9657821" position="982 2389" bounds="923 2364 119 50" textPosition="930 2365" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NR1H2,3:RXR:NR1H2,3 ligand:ANGPTL3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1536" reactomeId="6784898" position="2116 2418" bounds="2086 2407 60 22" textPosition="2088 2401"> <Properties> <displayName>ANGPTL3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1537" reactomeId="9658360" position="484 2175" bounds="445 2164 79 22" textPosition="445 2164" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="11" reactomeId="9024386" points="1190 551, 1234 551, 1264 550" position="1234 551" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="12" points="1588 593, 1189 593" /> <Input id="13" points="1117 590" /> <Input id="15" points="293 757, 300 653" /> <Input id="16" points="1162 542" /> <Input id="14" points="955 878, 1025 864" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> <Properties> <displayName>Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="18" reactomeId="9024326" points="619 403, 648 403, 698 402" position="648 403" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="19" points="567 360" /> <Input id="15" points="293 757, 293 652" /> </Inputs> <Outputs> <Output id="20" /> </Outputs> <Properties> <displayName>Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="21" reactomeId="9024334" points="831 400, 862 400, 892 400" position="862 400" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="22" points="903 441" /> <Output id="23" points="928 399" /> </Outputs> <Properties> <displayName>Co-repressor complex dissociates from the transcription unit of the ABCA1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="28" reactomeId="9029551" points="1097 399, 1123 399, 1159 399" position="1123 399" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="29" points="1068 363" /> <Input id="23" points="1061 398" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="9029561" points="1320 396, 1340 396, 1375 396" position="1340 396" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="30" points="1287 397" /> <Input id="32" points="1298 369" /> </Inputs> <Outputs> <Output id="33" /> </Outputs> <Properties> <displayName>NCOA1 recruits EP300 to the ABCA1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="9029521" points="1191 659, 1232 660, 1266 660" position="1232 660" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="45" points="1575 701, 1191 701" /> <Input id="14" points="955 880, 1035 868" /> <Input id="15" points="294 757, 305 666" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the ABCG5 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="47" reactomeId="9029531" points="1575 701, 1624 702, 2015 702" position="1624 702" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="45" /> </Inputs> <Outputs> <Output id="48" /> </Outputs> <Activators> <Activator id="46" points="1404 678, 1408 680, 1625 680" /> </Activators> <Properties> <displayName>Expression of ABCG5 regulated by NR1H2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="53" reactomeId="9024361" points="1588 593, 1626 594, 2021 594" position="1626 594" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="12" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> <Activators> <Activator id="17" points="1400 562, 1406 564, 1624 563" /> </Activators> <Properties> <displayName>Expression of ABCG1 regulated by NR1H2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="9029555" points="1177 767, 1230 766, 1264 766" position="1230 766" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="955 882, 1044 872" /> <Input id="15" points="296 757, 312 680" /> <Input id="57" points="1578 806, 1178 806" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the ABCG8 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="63" reactomeId="9029591" points="1578 806, 1626 805, 2024 805" position="1626 805" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="57" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Activators> <Activator id="58" points="1402 779, 1406 781, 1626 781" /> </Activators> <Properties> <displayName>Expression of ABCG8 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="9035133" points="1179 869, 1237 869, 1267 869" position="1237 869" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="955 884" /> <Input id="15" points="297 757, 318 689" /> <Input id="66" points="1573 903, 1178 903" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the CETP gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="76" reactomeId="9035169" points="1573 903, 1619 905, 2082 904" position="1619 905" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="77" /> </Outputs> <Activators> <Activator id="67" points="1405 877, 1413 879, 1618 879" /> </Activators> <Properties> <displayName>Expression of CETP regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="9031522" points="1253 1210, 1284 1209, 1285 1209" position="1284 1209" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="931 904, 1192 1008" /> <Input id="15" points="350 791, 626 853" /> <Input id="89" points="1538 1245, 1243 1247" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the APOE gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="9031512" points="1538 1245, 1592 1247, 2101 1247" position="1592 1247" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="89" /> </Inputs> <Outputs> <Output id="96" /> </Outputs> <Activators> <Activator id="90" points="1423 1211, 1592 1211" /> </Activators> <Properties> <displayName>Expression of APOE regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="97" reactomeId="9031518" points="1222 1310, 1266 1310, 1302 1310" position="1266 1310" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="929 904, 1165 1003" /> <Input id="15" points="350 792, 603 853" /> <Input id="98" points="1553 1350, 1217 1348" /> </Inputs> <Outputs> <Output id="99" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the APOC1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="100" reactomeId="9031510" points="1553 1350, 1603 1351, 2086 1342" position="1603 1351" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="98" /> </Inputs> <Outputs> <Output id="101" /> </Outputs> <Activators> <Activator id="99" points="1440 1318, 1453 1320, 1599 1321" /> </Activators> <Properties> <displayName>Expression of APOC1 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="102" reactomeId="9031521" points="1214 1403, 1244 1403, 1275 1403" position="1244 1403" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="928 904, 1139 998" /> <Input id="15" points="350 793, 576 851" /> <Input id="103" points="1554 1444, 1204 1443" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the APOC2 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="109" reactomeId="9031527" points="1554 1444, 1605 1444, 2083 1437" position="1605 1444" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="103" /> </Inputs> <Outputs> <Output id="110" /> </Outputs> <Activators> <Activator id="104" points="1413 1417, 1426 1421, 1603 1421" /> </Activators> <Properties> <displayName>Expression of APOC2 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="111" reactomeId="9035143" points="1171 1489, 1205 1487, 1229 1487" position="1205 1487" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="926 904, 1116 994" /> <Input id="15" points="350 794, 565 853" /> <Input id="112" points="1566 1527, 1166 1530" /> </Inputs> <Outputs> <Output id="113" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the APOC4 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="127" reactomeId="9035167" points="1063 1707, 1087 1708, 1113 1707" position="1087 1708" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="916 904, 1030 1009" /> <Input id="15" points="304 805, 379 913" /> <Input id="128" points="1573 1746, 1049 1745" /> </Inputs> <Outputs> <Output id="129" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the EEPD1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="130" reactomeId="9035180" points="1573 1746, 1629 1748, 2025 1747" position="1629 1748" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="128" /> </Inputs> <Outputs> <Output id="131" /> </Outputs> <Activators> <Activator id="129" points="1251 1716, 1306 1724, 1627 1725" /> </Activators> <Properties> <displayName>Expression of EEPD1 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="132" reactomeId="9035185" points="1259 1113, 1286 1113, 1315 1113" position="1286 1113" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="932 904, 1213 1011" /> <Input id="15" points="350 791, 649 852" /> <Input id="133" points="1525 1139, 1251 1141" /> </Inputs> <Outputs> <Output id="134" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the NR1H3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="139" reactomeId="9028533" points="963 1881, 1002 1882, 1048 1882" position="1002 1882" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="905 904" /> <Input id="15" points="303 805" /> <Input id="140" points="1572 1931, 957 1921" /> <Input id="141" points="554 2040" /> </Inputs> <Outputs> <Output id="142" /> </Outputs> <Properties> <displayName>NR1H2,3, NRIP1 bind the FASN gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="9028526" points="924 1970, 965 1969, 991 1969" position="965 1969" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="905 904" /> <Input id="15" points="302 805" /> <Input id="141" points="554 2044" /> <Input id="154" points="1571 2013, 915 2010" /> </Inputs> <Outputs> <Output id="155" /> </Outputs> <Properties> <displayName>NR1H2 or NR1H3, NRIP1 bind the SCD gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="166" reactomeId="9028525" points="866 2083, 929 2082, 964 2080" position="929 2082" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="167" points="1587 2114, 856 2122" /> <Input id="14" points="904 904" /> <Input id="15" points="300 805" /> <Input id="141" points="554 2051" /> </Inputs> <Outputs> <Output id="168" /> </Outputs> <Properties> <displayName>NR1H2 or NR1H3, NRIP1 bind the SREBF1gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="179" reactomeId="9028524" points="845 2174, 905 2172, 967 2172" position="905 2172" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="141" points="554 2057" /> <Input id="180" points="1593 2200, 811 2202" /> <Input id="15" points="300 805" /> <Input id="1537" points="530 2174" /> </Inputs> <Outputs> <Output id="181" /> </Outputs> <Properties> <displayName>NR1H3, NRIP1 bind the PCK1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="230" reactomeId="9029517" points="304 2496, 340 2498, 380 2497" position="340 2498" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15" points="293 805" /> <Input id="231" points="265 2495" /> </Inputs> <Outputs> <Output id="232" /> </Outputs> <Properties> <displayName>Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="233" reactomeId="9029566" points="515 2496, 538 2496, 567 2496" position="538 2496" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="232" /> </Inputs> <Outputs> <Output id="280" points="591 2496" /> <Output id="234" points="569 2459" /> </Outputs> <Properties> <displayName>Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="235" reactomeId="9029580" points="842 2501, 941 2502, 1042 2503" position="941 2502" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="280" points="724 2498" /> <Input id="648" points="814 2479" /> </Inputs> <Outputs> <Output id="316" /> </Outputs> <Properties> <displayName>NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="325" reactomeId="9029536" points="1610 2497, 1647 2497, 1906 2497, 1905 2229" position="1647 2497" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="326" /> </Inputs> <Outputs> <Output id="327" /> </Outputs> <Activators> <Activator id="316" points="1177 2485, 1190 2481, 1633 2476" /> </Activators> <Properties> <displayName>Expression of UGT1A3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="540" reactomeId="9035281" points="1525 1139, 1553 1138, 1702 1140" position="1553 1138" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="133" /> </Inputs> <Outputs> <Output id="649" /> </Outputs> <Activators> <Activator id="134" points="1432 1114, 1543 1114" /> </Activators> <Properties> <displayName>NR1H3 gene transcription regulated by NR1H2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="611" reactomeId="9035279" points="1566 1527, 1621 1527, 2085 1523" position="1621 1527" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="112" /> </Inputs> <Outputs> <Output id="612" /> </Outputs> <Activators> <Activator id="113" points="1367 1504, 1372 1507, 1615 1507" /> </Activators> <Properties> <displayName>Expression of APOC4 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="655" reactomeId="9038545" points="1841 1164, 1863 1164, 1892 1162" position="1863 1164" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="656" points="1825 1177" /> <Input id="649" points="1830 1159" /> </Inputs> <Outputs> <Output id="657" /> </Outputs> <Properties> <displayName>miR-613 binds to the 3'UTR of the NR1H3 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="659" reactomeId="9605063" points="1572 1931, 1638 1931, 1734 1932" position="1638 1931" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="140" /> </Inputs> <Outputs> <Output id="148" /> </Outputs> <Activators> <Activator id="142" points="1183 1905, 1194 1910, 1620 1912" /> </Activators> <Properties> <displayName>Expression of FASN regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="661" reactomeId="9605060" points="1571 2013, 1653 2013, 1821 2014" position="1653 2013" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="154" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> <Activators> <Activator id="155" points="1129 1983, 1151 1989, 1642 1992" /> </Activators> <Properties> <displayName>Expression of SCD regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="664" reactomeId="9605056" points="1587 2114, 1654 2114, 1818 2113" position="1654 2114" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="167" /> </Inputs> <Outputs> <Output id="1399" /> </Outputs> <Activators> <Activator id="168" points="1099 2078, 1650 2078" /> </Activators> <Properties> <displayName>Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="665" reactomeId="9605051" points="1593 2200, 1642 2200, 1747 2200" position="1642 2200" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="180" /> </Inputs> <Outputs> <Output id="183" /> </Outputs> <Inhibitors> <Inhibitor id="181" points="1097 2172, 1642 2181" /> </Inhibitors> <Properties> <displayName>Expression of PCK1 regulated by NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="727" reactomeId="9605052" points="1764 1127, 1764 1107, 1651 1082" position="1764 1107" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="649" /> </Inputs> <Outputs> <Output id="541" /> </Outputs> <Inhibitors> <Inhibitor id="657" points="1955 1140, 1955 1107" /> </Inhibitors> <Properties> <displayName>NR1H3 mRNA is translated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="733" reactomeId="9619756" points="2032 490, 2026 509, 2035 538" position="2026 509" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="342" points="2042 456" /> <Input id="734" points="1983 492" /> </Inputs> <Outputs> <Output id="735" /> </Outputs> <Properties> <displayName>NR1H2 binds ABCA1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1293" reactomeId="9618407" points="1040 1809, 1152 1808, 1213 1806" position="1152 1808" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15" points="304 805, 373 911" /> <Input id="14" points="906 904" /> <Input id="1294" points="1579 1840, 984 1839" /> </Inputs> <Outputs> <Output id="1295" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the ARL4C gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1345" reactomeId="9618394" points="1579 1840, 1647 1842, 1716 1832" position="1647 1842" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1294" /> </Inputs> <Outputs> <Output id="1346" /> </Outputs> <Activators> <Activator id="1295" points="1351 1818, 1363 1822, 1644 1823" /> </Activators> <Properties> <displayName>ARL4C gene transcription regulated by NR1H2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1347" reactomeId="9618405" points="1843 1823, 1864 1823, 1923 1824" position="1864 1823" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1346" /> </Inputs> <Outputs> <Output id="1348" /> </Outputs> <Inhibitors> <Inhibitor id="1349" points="1878 1847" /> </Inhibitors> <Properties> <displayName>ARL4C mRNA is translated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1350" reactomeId="9618392" points="1769 1855, 1792 1855, 1825 1859" position="1792 1855" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1346" points="1772 1838" /> <Input id="1351" points="1752 1860" /> </Inputs> <Outputs> <Output id="1349" /> </Outputs> <Properties> <displayName>miR-26 binds to the 3'UTR of the ARL4C mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1356" reactomeId="9623366" points="1115 1564, 1184 1564, 1259 1564" position="1184 1564" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="15" points="310 805, 392 881" /> <Input id="14" points="924 904, 1098 998" /> <Input id="1357" points="1556 1599, 1100 1600" /> </Inputs> <Outputs> <Output id="1358" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the MYLIP gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1359" reactomeId="9623365" points="1556 1599, 1613 1597, 1735 1596" position="1613 1597" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1357" /> </Inputs> <Outputs> <Output id="1360" /> </Outputs> <Activators> <Activator id="1358" points="1397 1571" /> </Activators> <Properties> <displayName>Expression of MYLIP regulated by NR1H2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1361" reactomeId="9624353" points="1205 959, 1237 959, 1269 960" position="1237 959" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1362" points="1586 994, 1205 995" /> <Input id="15" points="299 757, 322 703, 1025 844" /> <Input id="14" points="955 886, 1046 884" /> </Inputs> <Outputs> <Output id="1363" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the PLTP gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1366" reactomeId="9624365" points="1586 994, 1641 994, 2077 996" position="1641 994" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1362" /> </Inputs> <Outputs> <Output id="1367" /> </Outputs> <Activators> <Activator id="1363" points="1410 972, 1420 975, 1639 975" /> </Activators> <Properties> <displayName>Expression of PLTP regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1373" reactomeId="9608039" points="767 2252, 840 2251, 931 2249" position="840 2251" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="903 904" /> <Input id="15" points="298 805" /> <Input id="1374" points="1608 2285, 742 2291" /> </Inputs> <Outputs> <Output id="1375" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the PLIN1 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1376" reactomeId="9608048" points="1608 2285, 1648 2286, 1703 2311" position="1648 2286" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1374" /> </Inputs> <Outputs> <Output id="1377" /> </Outputs> <Inhibitors> <Inhibitor id="1375" points="1049 2248, 1648 2258" /> </Inhibitors> <Properties> <displayName>Expression of PLIN1 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1381" reactomeId="9631296" points="720 2323, 885 2324, 947 2322" position="885 2324" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="903 904" /> <Input id="15" points="297 805" /> <Input id="1382" points="1602 2359, 697 2357" /> </Inputs> <Outputs> <Output id="1398" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the FABP6 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1385" reactomeId="9607342" points="1602 2359, 1651 2361, 1712 2386" position="1651 2361" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1382" /> </Inputs> <Outputs> <Output id="1386" /> </Outputs> <Activators> <Activator id="1398" points="1060 2334, 1070 2338, 1644 2340" /> </Activators> <Properties> <displayName>Expression of FABP6 regulated by NR1H2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1429" reactomeId="9605057" points="1573 442, 1621 442, 1698 442" position="1621 442" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1430" /> </Inputs> <Outputs> <Output id="1431" /> </Outputs> <Activators> <Activator id="33" points="1510 407, 1616 424" /> </Activators> <Properties> <displayName>ABCA1 gene transcription regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1432" reactomeId="9618479" points="1803 442, 1901 442, 2018 442" position="1901 442" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1431" /> </Inputs> <Outputs> <Output id="342" /> </Outputs> <Inhibitors> <Inhibitor id="1433" points="1883 386, 1899 428" /> <Inhibitor id="1434" points="1940 344, 1953 361" /> <Inhibitor id="1441" points="1979 293, 2011 321, 1921 426" /> </Inhibitors> <Properties> <displayName>ABCA1 mRNA is translated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1436" reactomeId="9618486" points="1786 323, 1812 322, 1870 322" position="1812 322" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1431" points="1755 428" /> <Input id="1438" points="1752 303" /> </Inputs> <Outputs> <Output id="1434" /> </Outputs> <Properties> <displayName>miR-26 binds to the 3'UTR of the ABCA1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1439" reactomeId="9624925" points="1766 363, 1795 364, 1817 364" position="1795 364" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1440" points="1740 346" /> <Input id="1431" points="1753 428" /> </Inputs> <Outputs> <Output id="1433" /> </Outputs> <Properties> <displayName>miR-33 binds to the 3'UTR of the ABCA1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1442" reactomeId="9657791" points="1816 272, 1840 272, 1898 272" position="1840 272" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1443" points="1775 265" /> <Input id="1431" points="1757 428" /> </Inputs> <Outputs> <Output id="1441" /> </Outputs> <Properties> <displayName>miR-144 binds to the 3'UTR of the ABCA1 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1445" reactomeId="9657786" points="1088 1627, 1163 1628, 1267 1629" position="1163 1628" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="921 904, 1070 996" /> <Input id="1446" points="1586 1661, 1075 1663" /> <Input id="15" points="306 805, 352 860" /> </Inputs> <Outputs> <Output id="1447" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the APOD gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1448" reactomeId="9657767" points="1586 1661, 1624 1661, 2086 1657" position="1624 1661" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1446" /> </Inputs> <Outputs> <Output id="1449" /> </Outputs> <Activators> <Activator id="1447" points="1392 1642, 1399 1645, 1610 1645" /> </Activators> <Properties> <displayName>Expression of APOD regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1532" reactomeId="9657836" points="662 2389, 837 2389, 920 2389" position="837 2389" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="14" points="903 904" /> <Input id="1533" points="1605 2419, 646 2427" /> <Input id="15" points="297 805" /> </Inputs> <Outputs> <Output id="1534" /> </Outputs> <Properties> <displayName>NR1H2,3 binds the ANGPTL3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1535" reactomeId="9657775" points="1605 2419, 1648 2418, 2083 2418" position="1648 2418" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="1533" /> </Inputs> <Outputs> <Output id="1536" /> </Outputs> <Activators> <Activator id="1534" points="1045 2390, 1624 2408" /> </Activators> <Properties> <displayName>Expression of ANGPTL3 regulated by NR1H2 or NR1H3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="1538" points="481 2158, 474 2131, 415 870, 856 885" position="444 1500" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="1537" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> </Edges> <Pathways /> </Process>
width2154
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of NR1H2 and NR1H3-mediated signaling (9035469)
Follow Reactome