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Details on Person NR3C2 (MR) dissociates from HSP90 complex by ATP-dependent hydrolysis

Class:Id	BlackBoxEvent:9035361
_displayName	NR3C2 (MR) dissociates from HSP90 complex by ATP-dependent hydrolysis
_doRelease	FALSE
_timestamp	2020-03-10 17:22:17
authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
catalystActivity	[CatalystActivity:5618078] ATP hydrolysis activity of HSP90 complexes [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9035333] Shamovsky, Veronica, 2018-01-22
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
input	[DefinedSet:9677709] HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligand [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9035364] Nuclear shuttling precedes dimerization in mineralocorticoid receptor signaling [LiteratureReference:8938591] Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90
modified	[InstanceEdit:9676981] Shamovsky, Veronica, 2020-02-24 [InstanceEdit:9677722] Shamovsky, Veronica, 2020-03-10
name	NR3C2 (MR) dissociates from HSP90 complex by ATP-dependent hydrolysis
output	[SimpleEntity:113550] Pi [nucleoplasm] [DefinedSet:5082395] HSP90:HSP90 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:5082403] PTGES3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5324621] FKBP4 [nucleoplasm] [Homo sapiens] [DefinedSet:9035359] NR3C2:NR3C2 agonist [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9035340] HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligand translocates to the nucleus [Homo sapiens] [Reaction:9677238] Cortisol binds NR3C2 within the HSP90 chaperone complex [Homo sapiens] [Reaction:9028629] Mineralocorticoid binds NR3C2 within the HSP90 chaperone complex [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9035397] R-HSA-9035361.1
summation	[Summation:9035372] The unliganded mineralocorticoid receptor (MR or NR3C2) is l...
(hasEvent)	[Pathway:9028598] NR3C2 (MR)-mediated signaling [Homo sapiens]
(precedingEvent)	[Reaction:9035351] NR3C2 dimerizes [Homo sapiens]
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No pathways have been reviewed or authored by NR3C2 (MR) dissociates from HSP90 complex by ATP-dependent hydrolysis (9035361)