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Details on Person The liver X receptor alpha (LXRα or NR1H3) gene is transcrib...
| Class:Id | Summation:9035282 |
|---|---|
| _displayName | The liver X receptor alpha (LXRα or NR1H3) gene is transcrib... |
| _timestamp | 2019-08-14 04:18:20 |
| created | [InstanceEdit:9035280] Shamovsky, Veronica, 2018-01-20 |
| literatureReference | [LiteratureReference:9035146] Autoregulation of the human liver X receptor alpha promoter [LiteratureReference:9035156] Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism [LiteratureReference:9657863] Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages |
| modified | [InstanceEdit:9621101] Shamovsky, Veronica, 2018-09-26 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9658380] Shamovsky, Veronica, 2019-08-13 [InstanceEdit:9658427] Shamovsky, Veronica, 2019-08-14 |
| text | The liver X receptor alpha (LXRα or NR1H3) gene is transcribed to yield mRNA. The NR1H3 gene expression is auto-inducible ((Whitney KD et al. 2001; Laffitte BA et al. 2001; Li Y et al. 2002). NR1H3 (LXRα) induction was observed in multiple human cell types including monocyte-derived macrophages, the THP1 macrophage cell line and skin fibroblasts in response to NR1H3 and NR1H2 (LXRβ) ligands (20(S)hydroxycholesterol, 22(R)hydroxycholesterol, 24(S),25-epoxycholesterol, GW3965 or T0901317) (Whitney KD et al. 2001; Laffitte BA et al. 2001; Li Y et al. 2002). This induction was mediated via LXR response elements (LXREs) found within the NR1H3 promoter ((Whitney KD et al 2001; Laffitte BA et al. 2001; Li Y et al. 2002). The autoregulatory loop led to the selective induction of NR1H3 gene expression whereas NR1H2 (LXRβ) was not induced (Whitney KD et al. 2001; Lafitte B et al. 2001; Li Y et al. 2002). The increased NR1H3 levels induce expression of its downstream target genes such as ABCA1, ABCG1 providing a simple yet exquisite mechanism for cells to respond to LXRs ligands and cholesterol loading (Li Y et al. 2002). |
| (summation) | [BlackBoxEvent:9035281] NR1H3 gene transcription regulated by NR1H2,3 [Homo sapiens] |
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