Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Based on the accepted model of PLCgamma1 (PLCG1) signaling, ...

Class:IdSummation:9034856
_displayNameBased on the accepted model of PLCgamma1 (PLCG1) signaling, ...
_timestamp2018-03-26 23:43:31
created[InstanceEdit:9034857] Orlic-Milacic, Marija, 2018-01-12
modified[InstanceEdit:9603891] Orlic-Milacic, Marija, 2018-03-26
textBased on the accepted model of PLCgamma1 (PLCG1) signaling, although this has not been tested in the context of the NTRK3 (TRKC) receptor-mediated activation of PLCG1, phosphorylated, active, PLCG1 dissociates from the receptor tyrosine kinase and catalyzes formation of DAG and IP3 second messengers (Carpenter and Ji 1999). Activation of rat Ntrk3 by human NTF3 (NT-3) is known to result in tyrosine phosphorylation of rat Plcg1 and activation of DAG and IP3 signaling (Marsh and Palfrey 1996).
(summation)[BlackBoxEvent:9034855] Activated PCLG1 dissociates from NTRK3 [Homo sapiens]
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No pathways have been reviewed or authored by Based on the accepted model of PLCgamma1 (PLCG1) signaling, ... (9034856)