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Details on Person UniProt:P24786 NTRK3
| Class:Id | ReferenceGeneProduct:9034609 |
|---|---|
| _displayName | UniProt:P24786 NTRK3 |
| _timestamp | 2025-02-21 18:49:45 |
| chain | signal peptide:1-31 chain:32-825 |
| checksum | A3C6716B10D28540 |
| comment | FUNCTION Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220. Interacts with PTPRS (By similarity). Interacts with MAPK8IP3/JIP3 (By similarity).SUBCELLULAR LOCATION Preferentially in the brain, low levels in the ovaries.PTM Ligand-mediated auto-phosphorylation.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| created | [InstanceEdit:9034608] Orlic-Milacic, Marija, 2018-01-08 |
| description | recommendedName: NT-3 growth factor receptor ecNumber: 2.7.10.1 alternativeName: GP145-TrkC shortName: Trk-C alternativeName: Neurotrophic tyrosine kinase receptor type 3 alternativeName: TrkC tyrosine kinase |
| geneName | NTRK3 TRKC |
| identifier | P24786 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Developmental protein Differentiation Disulfide bond Glycoprotein Immunoglobulin domain Kinase Leucine-rich repeat Membrane Neurogenesis Nucleotide-binding Phosphoprotein Receptor Reference proteome Repeat Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NTRK3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NTRK3_PIG |
| sequenceLength | 825 |
| species | [Species:49633] Sus scrofa |
| (referenceEntity) | [EntityWithAccessionedSequence:9034603] Ntrk3 [plasma membrane] [Sus scrofa] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P24786 NTRK3 (9034609)
