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Details on Person The trypsin-like serine-type endopeptidase TYSND1 cleaves HS...
| Class:Id | Summation:9034347 |
|---|---|
| _displayName | The trypsin-like serine-type endopeptidase TYSND1 cleaves HS... |
| _timestamp | 2018-03-12 07:50:32 |
| created | [InstanceEdit:9034346] May, Bruce, 2018-01-04 |
| modified | [InstanceEdit:9034452] May, Bruce, 2018-01-05 [InstanceEdit:9036006] May, Bruce, 2018-01-27 [InstanceEdit:9036907] May, Bruce, 2018-02-13 [InstanceEdit:9038630] May, Bruce, 2018-03-12 |
| text | The trypsin-like serine-type endopeptidase TYSND1 cleaves HSD17B4 (Peroxisomal multifunctional enzyme type 2, MFP-2) between amino acid residues 311 and 312, yielding HSD17B4(1-311) and HSD17B4(312-736) (Okumoto et al. 2011, also inferred from mouse homologs). HSD17B4(1-311) dehydrogenates 3-hydroxyacyl-CoA; HSD17B4(312-736) acts as an enoyl-CoA hydratase (Jiang et al. 1997, reviewed in Huyghe et al. 2006). (In vitro, HSD17B4(312-736) facilitates the transfer of 7-dehydrocholesterol and phosphatidylcholine between membranes.) The uncleaved protein (HSD17B4) also catalyzes these reactions. |
| (summation) | [Reaction:9033530] TYSND1 cleaves HSD17B4 [Homo sapiens] |
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