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Details on Person PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3

Class:Id	Reaction:9033527
_displayName	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3
_doRelease	TRUE
_timestamp	2018-03-12 07:44:10
authored	[InstanceEdit:9033237] May, Bruce, 2017-12-19
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033525] May, Bruce, 2017-12-22
edited	[InstanceEdit:9033237] May, Bruce, 2017-12-19
input	[Complex:9033513] PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Homo sapiens] [Complex:8953915] Ub:UBE2D1,2,3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8953922] Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor [LiteratureReference:8953919] Properties of the ubiquitin-pex5p thiol ester conjugate [LiteratureReference:8953918] Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling [LiteratureReference:9033608] Ubiquitination of mammalian Pex5p, the peroxisomal import receptor [LiteratureReference:9036564] PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import
modified	[InstanceEdit:9033626] May, Bruce, 2017-12-23 [InstanceEdit:9033909] May, Bruce, 2017-12-28 [InstanceEdit:9036576] May, Bruce, 2018-02-05 [InstanceEdit:9036919] May, Bruce, 2018-02-13 [InstanceEdit:9038630] May, Bruce, 2018-03-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3
output	[Complex:9033521] PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9033514] Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix [Homo sapiens] [Reaction:9033238] PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) [Homo sapiens]
releaseDate	2018-03-18
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9033574] R-HSA-9033527.3
summation	[Summation:9033902] A RING E3 ubiquitin ligase sub-complex containing PEX10, PEX...
(hasEvent)	[Pathway:9033241] Peroxisomal protein import [Homo sapiens]
(precedingEvent)	[Reaction:9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779467] Update Tracker - [Reaction:9033527] PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 - v65:[modifyText]
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No pathways have been reviewed or authored by PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (9033527)