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Details on Person PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12

Class:Id	BlackBoxEvent:9033505
_displayName	PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12
_doRelease	TRUE
_timestamp	2018-03-12 07:43:56
authored	[InstanceEdit:9033237] May, Bruce, 2017-12-19
catalystActivity	[CatalystActivity:9033905] ATPase-coupled transmembrane transporter activity of PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane]
catalystActivityReference	[CatalystActivityReference:9643097] ATPase activity, coupled to movement of substances of PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033525] May, Bruce, 2017-12-22
edited	[InstanceEdit:9033237] May, Bruce, 2017-12-19
inferredFrom	[BlackBoxEvent:9033756] PEX1:PEX6:PEX15:Ub:PEX5:PEX14:PEX13:PEX17:PEX1:PEX6:PEX15 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX17:PEX1:PEX6:PEX15 [Saccharomyces cerevisiae]
input	[SimpleEntity:113592] ATP [cytosol] [Complex:9033488] PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9033745] The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders [LiteratureReference:9033761] AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import [LiteratureReference:9033866] Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes [LiteratureReference:9033849] Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I [LiteratureReference:9033631] AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase
modified	[InstanceEdit:9033626] May, Bruce, 2017-12-23 [InstanceEdit:9033788] May, Bruce, 2017-12-27 [InstanceEdit:9033892] May, Bruce, 2017-12-28 [InstanceEdit:9033909] May, Bruce, 2017-12-28 [InstanceEdit:9033933] May, Bruce, 2017-12-29 [InstanceEdit:9036915] May, Bruce, 2018-02-13 [InstanceEdit:9036919] May, Bruce, 2018-02-13 [InstanceEdit:9038630] May, Bruce, 2018-03-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12
output	[SimpleEntity:29370] ADP [cytosol] [Complex:9033100] PEX1:PEX6:PEX26 [peroxisomal membrane] [Homo sapiens] [DefinedSet:9033619] Ub:PEX5S,L [cytosol] [Homo sapiens] [Complex:9033606] PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:9033138] ZFAND6 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9033533] PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 [Homo sapiens] [Reaction:8953946] PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 [Homo sapiens]
releaseDate	2018-03-18
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9033579] R-HSA-9033505.4
summation	[Summation:9033881] Ubiquitinated PEX5 isoform S or isoform L (Ub:PEX5S,L) is re...
(hasEvent)	[Pathway:9033241] Peroxisomal protein import [Homo sapiens]
(precedingEvent)	[Reaction:9033478] USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin [Homo sapiens] [Reaction:9033509] USP9X binds Ub:PEX5L [Homo sapiens] [Reaction:9033526] USP9X binds Ub:PEX5S [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779636] Update Tracker - [BlackBoxEvent:9033505] PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 - v65:[modifyText]
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No pathways have been reviewed or authored by PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (9033505)