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Details on Person PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11

Class:Id	Reaction:9033485
_displayName	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11
_doRelease	TRUE
_timestamp	2018-03-12 07:44:40
authored	[InstanceEdit:8953941] May, Bruce, 2017-01-01
catalystActivity	[CatalystActivity:9034385] ubiquitin protein ligase activity of PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane]
catalystActivityReference	[CatalystActivityReference:9643722] ubiquitin protein ligase activity of PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033525] May, Bruce, 2017-12-22
edited	[InstanceEdit:8953941] May, Bruce, 2017-01-01
input	[Complex:9033521] PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8953922] Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor [LiteratureReference:8953919] Properties of the ubiquitin-pex5p thiol ester conjugate [LiteratureReference:8953918] Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling [LiteratureReference:8963766] Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor [LiteratureReference:8963764] Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts [LiteratureReference:8963776] ATM functions at the peroxisome to induce pexophagy in response to ROS [LiteratureReference:8963760] PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation [LiteratureReference:9033005] A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway
modified	[InstanceEdit:9034387] May, Bruce, 2018-01-04 [InstanceEdit:9036919] May, Bruce, 2018-02-13 [InstanceEdit:9038630] May, Bruce, 2018-03-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11
output	[Complex:9033497] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] [Homo sapiens] [DefinedSet:1234120] UBE2D1,2,3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9033527] PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 [Homo sapiens] [BlackBoxEvent:9033514] Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix [Homo sapiens]
releaseDate	2018-03-18
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9033573] R-HSA-9033485.4
summation	[Summation:9038629] The RING-type E3 ubiquitin ligase sub-complex PEX2:PEX10:PEX...
(hasEvent)	[Pathway:9033241] Peroxisomal protein import [Homo sapiens]
(precedingEvent)	[Reaction:9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779475] Update Tracker - [Reaction:9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 - v65:[add_removeSummation]
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