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Details on Person NTRK2 promotes TIAM1 phosphorylation

Class:IdBlackBoxEvent:9033284
_displayNameNTRK2 promotes TIAM1 phosphorylation
_doReleaseTRUE
_timestamp2018-02-20 17:56:29
authored[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity[CatalystActivity:9033287] protein tyrosine kinase activity of BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9033286] Orlic-Milacic, Marija, 2017-12-20
edited[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
inferredFrom
input[Complex:9033279] BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
modified[InstanceEdit:9033340] Orlic-Milacic, Marija, 2017-12-20
[InstanceEdit:9037702] Orlic-Milacic, Marija, 2018-02-20
[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
[InstanceEdit:9037704] Orlic-Milacic, Marija, 2018-02-20
[InstanceEdit:9037712] Orlic-Milacic, Marija, 2018-02-20
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNTRK2 promotes TIAM1 phosphorylation
output[Complex:9033288] BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2018-03-21
reviewed[InstanceEdit:9037707] Antila, Hanna, 2018-02-13
[InstanceEdit:9037710] Castrén, Eero, 2018-02-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9033289] R-HSA-9033284.2
summation[Summation:9033285] Upon binding to NTRK2 (TRKB), TIAM1 is phosphorylated at tyr...
(hasEvent)[Pathway:9032845] Activated NTRK2 signals through CDK5 [Homo sapiens]
(precedingEvent)[Reaction:9033292] NTRK2 and CDK5 promote activation of RAC1 by TIAM1 [Homo sapiens]
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No pathways have been reviewed or authored by NTRK2 promotes TIAM1 phosphorylation (9033284)