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Details on Person PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)

Class:Id	Reaction:9033236
_displayName	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
_doRelease	TRUE
_timestamp	2018-03-12 07:46:52
authored	[InstanceEdit:9033239] May, Bruce, 2017-12-18
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033234] May, Bruce, 2017-12-19
edited	[InstanceEdit:9033239] May, Bruce, 2017-12-18
input	[Complex:9033606] PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Homo sapiens] [Complex:9033153] PEX5S,L:Cargo protein [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9033043] Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import [LiteratureReference:9033000] The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo [LiteratureReference:9033066] A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway [LiteratureReference:9033021] PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14 [LiteratureReference:9033001] Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering [LiteratureReference:9033044] Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19 [LiteratureReference:9033617] A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes [LiteratureReference:9033833] Identification and characterization of the human orthologue of yeast Pex14p [LiteratureReference:9036563] Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor
modified	[InstanceEdit:9033584] May, Bruce, 2017-12-22 [InstanceEdit:9033626] May, Bruce, 2017-12-23 [InstanceEdit:9033892] May, Bruce, 2017-12-28 [InstanceEdit:9036576] May, Bruce, 2018-02-05 [InstanceEdit:9036919] May, Bruce, 2018-02-13 [InstanceEdit:9038630] May, Bruce, 2018-03-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
output	[Complex:9033114] PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] [Homo sapiens]
precedingEvent	[Reaction:9033233] PEX5S,L binds cargo proteins containing PTS1 [Homo sapiens]
releaseDate	2018-03-18
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9033245] R-HSA-9033236.3
summation	[Summation:9033610] PEX5S or PEX5L bound to cargo proteins containing PTS1 inter...
(hasEvent)	[Pathway:9033241] Peroxisomal protein import [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779584] Update Tracker - [Reaction:9033236] PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) - v65:[modifyText]
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No pathways have been reviewed or authored by PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (9033236)