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Details on Person PEX5S,L binds cargo proteins containing PTS1

Class:Id	Reaction:9033233
_displayName	PEX5S,L binds cargo proteins containing PTS1
_doRelease	TRUE
_timestamp	2018-03-12 07:46:36
authored	[InstanceEdit:9032610] May, Bruce, 2017-12-15
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9033234] May, Bruce, 2017-12-19
edited	[InstanceEdit:9032610] May, Bruce, 2017-12-15
inferredFrom	[Reaction:9033925] Pex5l binds Acox1 or Uox [Mus musculus]
input	[DefinedSet:9033111] Cargo proteins containing PTS1 [cytosol] [Homo sapiens] [DefinedSet:9033603] PEX5S,L [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9033040] Correlating structure and affinity for PEX5:PTS1 complexes [LiteratureReference:9033008] PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12 [LiteratureReference:9033051] Protein structure and import into the peroxisomal matrix [LiteratureReference:9033049] Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5 [LiteratureReference:9033031] Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders [LiteratureReference:9033006] Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders [LiteratureReference:9033021] PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14 [LiteratureReference:9033011] A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities [LiteratureReference:9033508] Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix [LiteratureReference:9036551] Characterization of the yeast and human receptors for the carboxy-terminal tripeptide peroxisomal targeting signal [LiteratureReference:9036588] Pex5p imports folded tetrameric catalase by interaction with Pex13p [LiteratureReference:9036902] The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it [LiteratureReference:9036901] Peroxisome targeting signal 1: is it really a simple tripeptide? [LiteratureReference:9033043] Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import [LiteratureReference:9033036] An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes [LiteratureReference:9033919] The peroxisomal protein import machinery displays a preference for monomeric substrates [LiteratureReference:9033827] A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform
modified	[InstanceEdit:9033584] May, Bruce, 2017-12-22 [InstanceEdit:9033593] May, Bruce, 2017-12-22 [InstanceEdit:9033626] May, Bruce, 2017-12-23 [InstanceEdit:9033933] May, Bruce, 2017-12-29 [InstanceEdit:9036576] May, Bruce, 2018-02-05 [InstanceEdit:9036591] May, Bruce, 2018-02-05 [InstanceEdit:9036907] May, Bruce, 2018-02-13 [InstanceEdit:9036915] May, Bruce, 2018-02-13 [InstanceEdit:9036919] May, Bruce, 2018-02-13 [InstanceEdit:9038630] May, Bruce, 2018-03-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PEX5S,L binds cargo proteins containing PTS1
output	[Complex:9033153] PEX5S,L:Cargo protein [cytosol] [Homo sapiens]
releaseDate	2018-03-18
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9033242] R-HSA-9033233.3
summation	[Summation:9033620] It is unclear how the long isoform of PEX5 (PEX5L) and the s...
(hasEvent)	[Pathway:9033241] Peroxisomal protein import [Homo sapiens]
(precedingEvent)	[Reaction:9033236] PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779484] Update Tracker - [Reaction:9033233] PEX5S,L binds cargo proteins containing PTS1 - v65:[addLiteratureReference, modifyText]
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