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Details on Person NTRK2-bound FYN autophosphorylates

Class:Id	BlackBoxEvent:9032532
_displayName	NTRK2-bound FYN autophosphorylates
_doRelease	TRUE
_timestamp	2018-02-20 17:56:29
authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9032538] protein tyrosine kinase activity of BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9032531] Orlic-Milacic, Marija, 2017-12-13
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
inferredFrom	[BlackBoxEvent:9032568] Ntrk2-bound Fyn autophosphorylates [Rattus norvegicus]
input	[Complex:9032501] BDNF:p-5Y-NTRK2 homodimer:MyrG-FYN-1 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:9032540] Orlic-Milacic, Marija, 2017-12-13 [InstanceEdit:9032557] Orlic-Milacic, Marija, 2017-12-14 [InstanceEdit:9032563] Orlic-Milacic, Marija, 2017-12-14 [InstanceEdit:9032571] Orlic-Milacic, Marija, 2017-12-14 [InstanceEdit:9037702] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9037704] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9037712] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK2-bound FYN autophosphorylates
output	[Complex:9032537] BDNF:p-5Y-NTRK2 homodimer:MyrG,p-Y420-FYN-1 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9032502] Activated NTRK2 binds FYN [Homo sapiens] [Reaction:9026464] BDNF-bound NTRK2 dimers trans-autophosphorylate [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9032533] R-HSA-9032532.2
summation	[Summation:9032551] Upon binding to BDNF-activated NTRK2 (TRKB) receptor, autoph...
(hasEvent)	[Pathway:9032500] Activated NTRK2 signals through FYN [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9032582] Activated FYN binds GRIN2B [Homo sapiens] [BlackBoxEvent:9032761] DOCK3 binds FYN associated with NTRK2 [Homo sapiens]
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No pathways have been reviewed or authored by NTRK2-bound FYN autophosphorylates (9032532)