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Details on Person Activation of NTRK2 (TrkB) by binding to BDNF or NTF4 (NT-4)...

Class:IdSummation:9031933
_displayNameActivation of NTRK2 (TrkB) by binding to BDNF or NTF4 (NT-4)...
_timestamp2017-12-04 16:24:29
created[InstanceEdit:9031935] Orlic-Milacic, Marija, 2017-12-04
literatureReference[LiteratureReference:9031564] Structural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB
[LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events
[LiteratureReference:9031568] Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3
modified[InstanceEdit:9031940] Orlic-Milacic, Marija, 2017-12-04
[InstanceEdit:9031941] Orlic-Milacic, Marija, 2017-12-04
[InstanceEdit:9031942] Orlic-Milacic, Marija, 2017-12-04
textActivation of NTRK2 (TrkB) by binding to BDNF or NTF4 (NT-4) leads to phosphorylation of FRS2 (also known as SNT or FRS2alpha) (Yuen and Mobley 1999). FRS2 binds to phosphorylated tyrosine Y516 of activated NTRK2 (Zeng et al. 2014 - Y516 is mislabeled as Y512 in the paper). Human FRS2 was also shown to bind to intracellular domain of rat Ntrk2 (Dixon et al. 2006).
(summation)[Reaction:9028730] Activated NTRK2 binds FRS2 [Homo sapiens]
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