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Details on Person Expression of APOE regulated by NR1H2 or NR1H3

Class:Id	BlackBoxEvent:9031512
_displayName	Expression of APOE regulated by NR1H2 or NR1H3
_doRelease	TRUE
_timestamp	2019-08-12 15:20:21
authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9031514] Shamovsky, Veronica, 2017-11-30
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
input	[EntityWithAccessionedSequence:8869591] APOE gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9629276] LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes [LiteratureReference:9609407] Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol
modified	[InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9618484] Shamovsky, Veronica, 2018-09-07 [InstanceEdit:9629273] Shamovsky, Veronica, 2018-11-20 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9637777] Shamovsky, Veronica, 2019-02-19 [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 [InstanceEdit:9658282] Shamovsky, Veronica, 2019-08-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of APOE regulated by NR1H2 or NR1H3
output	[EntityWithAccessionedSequence:174646] APOE [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9031522] NR1H2,3 binds the APOE gene [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9035445] Positive gene expression regulation by 'NR1H2,3:RXR:NR1H2,3 ligand:APOE gene [nucleoplasm]'
releaseDate	2019-09-10
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9031534] R-HSA-9031512.2
summation	[Summation:9031511] The apolipoprotein E (APOE) gene is transcribed to yield mRN...
(hasEvent)	[Pathway:9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux [Homo sapiens]
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No pathways have been reviewed or authored by Expression of APOE regulated by NR1H2 or NR1H3 (9031512)