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Details on Person BDNF-bound Ntrk2 dimers trans-autophosphorylate

Class:Id	Reaction:9030372
_displayName	BDNF-bound Ntrk2 dimers trans-autophosphorylate
_doRelease	TRUE
_timestamp	2018-02-20 18:57:43
authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9030396] protein tyrosine kinase activity of BDNF:Ntrk2 homodimer [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9030371] Orlic-Milacic, Marija, 2017-11-27
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
input	[Complex:9030373] BDNF:Ntrk2 homodimer [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	TRUE
literatureReference	[LiteratureReference:9026585] Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis [LiteratureReference:9026468] The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL
modified	[InstanceEdit:9030399] Orlic-Milacic, Marija, 2017-11-27 [InstanceEdit:9037725] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BDNF-bound Ntrk2 dimers trans-autophosphorylate
output	[Complex:9030369] BDNF:p-5Y-Ntrk2 homodimer [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stableIdentifier	[StableIdentifier:9030378] R-NUL-9030372.2
summation	[Summation:9030368] A recombinant human BDNF-induced dimerization of the rat rec...
(inferredFrom)	[Reaction:9026464] BDNF-bound NTRK2 dimers trans-autophosphorylate [Homo sapiens]
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No pathways have been reviewed or authored by BDNF-bound Ntrk2 dimers trans-autophosphorylate (9030372)