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Details on Person Phosphorylated JAK2 associated with the EPOR complex phospho...

Class:IdSummation:9030350
_displayNamePhosphorylated JAK2 associated with the EPOR complex phospho...
_timestamp2017-11-27 09:58:57
created[InstanceEdit:9030351] May, Bruce, 2017-11-27
textPhosphorylated JAK2 associated with the EPOR complex phosphorylates SHC1 (Damen et al. 1993, Verma et al. 2014) bound to CRKL in the EPOR complex. The phosphorylated SHC1 serves as a scaffold to bind downstream effectors including GRB2:VAV1 and GRB2:SOS1.
(summation)[Reaction:9029155] JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 [Homo sapiens]
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