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Details on Person Phosphorylated Jak2 associated with the Epor complex phospho...

Class:IdSummation:9030344
_displayNamePhosphorylated Jak2 associated with the Epor complex phospho...
_timestamp2017-11-27 09:58:47
created[InstanceEdit:9030351] May, Bruce, 2017-11-27
textPhosphorylated Jak2 associated with the Epor complex phosphorylates Shc1 bound to Crkl in the Epor complex (Damen et al. 1993, Miura et al. 1994, Zochodne et al. 2000). Shc1 may also bind Jak2 directly (He et al. 1995). The phosphorylated Shc1 serves as a scaffold to bind downstream effectors including Grb2:Vav1 and Grb2:Sos1 (Miura et al. 1994).
(summation)[Reaction:9029147] Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1 [Mus musculus]
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