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Details on Person Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene

Class:Id	Reaction:9029566
_displayName	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene
_doRelease	TRUE
_timestamp	2019-08-12 15:16:51
authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9029533] Shamovsky, Veronica, 2017-11-20
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
input	[Complex:9029556] UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOR [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9024438] The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice [LiteratureReference:9024340] Liver X receptor biology and pharmacology: new pathways, challenges and opportunities
modified	[InstanceEdit:9035264] Shamovsky, Veronica, 2018-01-20 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9637777] Shamovsky, Veronica, 2019-02-19 [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 [InstanceEdit:9658262] Shamovsky, Veronica, 2019-08-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene
output	[DefinedSet:349716] NCOR1, NCOR2 [nucleoplasm] [Homo sapiens] [Complex:9035263] UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9029517] Oxysterol binds to the UGT1A3 gene:NR1H2,3:RXR:NCOR complex [Homo sapiens]
releaseDate	2019-09-10
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9029605] R-HSA-9029566.2
summation	[Summation:9029523] In transient transfection assays performed in human hepatoma...
(hasEvent)	[Pathway:9623433] NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis [Homo sapiens]
(precedingEvent)	[Reaction:9029580] NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex [Homo sapiens]
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No pathways have been reviewed or authored by Co-repressor complex dissociates from the transcription unit of the UGT1A3 gene (9029566)