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Details on Person Activation of liver X receptors LXRα (NR1H3) and LXRβ (NR1H2...
| Class:Id | Summation:9029539 |
|---|---|
| _displayName | Activation of liver X receptors LXRα (NR1H3) and LXRβ (NR1H2... |
| _timestamp | 2019-08-09 09:03:11 |
| created | [InstanceEdit:9029533] Shamovsky, Veronica, 2017-11-20 |
| literatureReference | [LiteratureReference:9029582] Role of p160 coactivator complex in the activation of liver X receptor [LiteratureReference:9029527] Review of the in vivo functions of the p160 steroid receptor coactivator family [LiteratureReference:9029560] p300/CBP proteins: HATs for transcriptional bridges and scaffolds [LiteratureReference:9029583] Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family [LiteratureReference:9024455] Heterodimeric interaction between retinoid X receptor alpha and orphan nuclear receptor OR1 reveals dimerization-induced activation as a novel mechanism of nuclear receptor activation |
| modified | [InstanceEdit:9611807] Shamovsky, Veronica, 2018-06-19 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 |
| text | Activation of liver X receptors LXRα (NR1H3) and LXRβ (NR1H2) induces expression of ATP-binding cassette transporter A1 (ABCA1) (Jakobsson T et al. 2009). NR1H2,3 form functional dimers with retinoid X receptors (RXR) that bind to LXR-response elements (LXREs) in the DNA of target genes (Wiebel FF & Gustafsson JA 1997). Nuclear receptor coactivator 1 (NCOA1, also known as SRC1) binds to the ABCA1 gene promoter via oxysterol-induced NR1H3:RXR heterodimer (Huuskonen J et al. 2004). NCOA1 recruits E1A-associated protein p300 (EP300 or p300) leading to a maximal activation of ABCA1 promoter activity (Huuskonen J et al. 2004). EP300 are homologous coactivators capable of binding to the AD1 domain of p160 coactivators such as NCOA1. EP300, NCOA1 and other members of the p160 coactivator complex contribute to active chromatin structures via coactivator binding activity, acetylation or methylation of histones and other components of the transcription unit (reviewed in Xu J & Li Q 2003; Xu L et al. 2009; Chan HM & La Thangue NB 2001). |
| (summation) | [Reaction:9029561] NCOA1 recruits EP300 to the ABCA1 promoter [Homo sapiens] |
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