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Details on Person JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1

Class:IdReaction:9029151
_displayNameJAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
_doReleaseTRUE
_timestamp2018-08-14 15:54:45
authored[InstanceEdit:9029159] May, Bruce, 2017-11-11
catalystActivity[CatalystActivity:9029160] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643524] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] The signal transduction through Grb2/Ash in hematopoietic cells
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9029161] May, Bruce, 2017-11-14
edited[InstanceEdit:9029159] May, Bruce, 2017-11-11
inferredFrom
input[Complex:9029110] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9029007] The signal transduction through Grb2/Ash in hematopoietic cells
[LiteratureReference:9029048] Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity
modified[InstanceEdit:9030367] May, Bruce, 2017-11-27
[InstanceEdit:9616794] Matthews, Lisa, 2018-08-14
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameJAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1
output[Complex:9029112] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:p-Y-VAV1 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2018-09-12
reviewed[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9029166] R-HSA-9029151.3
summation[Summation:9030342] Phosphorylated JAK2 phosphorylates VAV1 bound to GRB2 in a l...
(hasEvent)[Pathway:9027284] Erythropoietin activates RAS [Homo sapiens]
(precedingEvent)[Reaction:9029158] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS [Homo sapiens]
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No pathways have been reviewed or authored by JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (9029151)
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