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Details on Person Progesterone binds NR3C2 within the HSP90 chaperone complex

Class:Id	Reaction:9028656
_displayName	Progesterone binds NR3C2 within the HSP90 chaperone complex
_doRelease	FALSE
_timestamp	2020-03-02 22:19:09
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9028579] Shamovsky, Veronica, 2017-11-09
input	[Complex:9028549] HSP90:ATP:FKBP4:PTGES3:NR3C2 [cytosol] [Homo sapiens] [SimpleEntity:193055] P4 [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9028614] Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor [LiteratureReference:9028631] Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands [LiteratureReference:8948327] Allosteric modulators of steroid hormone receptors: structural dynamics and gene regulation [LiteratureReference:9036355] A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor
modified	[InstanceEdit:9635715] Shamovsky, Veronica, 2019-02-08 [InstanceEdit:9677299] Shamovsky, Veronica, 2020-03-02
name	Progesterone binds NR3C2 within the HSP90 chaperone complex
output	[Complex:9028556] HSP90:ATP:FKBP4:PTGES3:NR3C2:progesterone [cytosol] [Homo sapiens]
precedingEvent	[Reaction:5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein [Homo sapiens] [Reaction:5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein [Homo sapiens] [Reaction:5618110] p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein [Homo sapiens] [Reaction:5618085] FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9028689] R-HSA-9028656.1
summation	[Summation:9028597] Mineralocorticoid receptor (MR or NR3C2) is a member of the ...
(hasEvent)	[Pathway:9028598] NR3C2 (MR)-mediated signaling [Homo sapiens]
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No pathways have been reviewed or authored by Progesterone binds NR3C2 within the HSP90 chaperone complex (9028656)