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Details on Person Interleukins (IL) are immunomodulatory proteins that elicit ...
| Class:Id | Summation:9028367 |
|---|---|
| _displayName | Interleukins (IL) are immunomodulatory proteins that elicit ... |
| _timestamp | 2017-11-07 14:46:33 |
| created | [InstanceEdit:9028366] Varusai, Thawfeek, 2017-11-07 |
| literatureReference | [LiteratureReference:9008566] The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines [LiteratureReference:8848516] Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production [LiteratureReference:9008582] IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp [LiteratureReference:9008686] Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses |
| modified | [InstanceEdit:9028373] Varusai, Thawfeek, 2017-11-07 |
| text | Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. The processing of IL-37 begins by the binding of Caspase to the protein. This is a black box event because the precise Caspase binding site in IL-37 is unclear. |
| (summation) | [BlackBoxEvent:9012542] IL37 binds 2x(CASP1(120-197):CASP1(317-404)) [Homo sapiens] |
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No pathways have been reviewed or authored by Interleukins (IL) are immunomodulatory proteins that elicit ... (9028367)
