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Details on Person UniProt:A0A096MJZ0 Dnal1
| Class:Id | ReferenceGeneProduct:9027697 |
|---|---|
| _chainChangeLog | initiator methionine:1 for 9027697 removed on Fri Nov 03 2023;initiator methionine: for 9027697 added on Fri Nov 03 2023;initiator methionine: for 9027697 removed on Fri Aug 15 2025;initiator methionine:1 for 9027697 added on Fri Aug 15 2025 |
| _displayName | UniProt:A0A096MJZ0 Dnal1 |
| _timestamp | 2025-08-15 22:00:02 |
| chain | initiator methionine:1 chain:2-190 |
| checksum | 679B7E227994495F |
| comment | FUNCTION Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry (By similarity).SUBUNIT Interacts with ZMYND10 (via C-terminus) (By similarity). Interacts with DNAH5, a outer arm dynein heavy chain (PubMed:21496787). Interacts with tubulin located within the A-tubule of the outer doublets in a ATP-independent manner (PubMed:21496787).SUBCELLULAR LOCATION Outer (ODAs) and inner (IDAs) dynein arms contain the molecular motors that generate the force to move cilia by ATP-dependent reactions. There are two mechanosensory systems that monitor and respond to the mechanical state (curvature) of the axoneme. One system involves the central pair microtubule complex and radial spokes and the second system involves the outer dynein arms.SIMILARITY Belongs to the dynein light chain LC1-type family. |
| created | [InstanceEdit:9027688] Weiser, JD |
| description | recommendedName: fullName evidence="1"Dynein axonemal light chain 1 shortName evidence="2"LC1 |
| geneName | Dnal1 |
| identifier | A0A096MJZ0 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell projection Cytoplasm Cytoskeleton Dynein Leucine-rich repeat Microtubule Motor protein Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Dnal1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DNAL1_RAT |
| sequenceLength | 190 |
| species | [Species:48895] Rattus norvegicus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A0A096MJZ0 Dnal1 (9027697)
