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Details on Person LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2

Class:IdReaction:9027425
_displayNameLYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
_doReleaseTRUE
_timestamp2018-08-14 15:55:20
authored[InstanceEdit:9027411] May, Bruce, 2017-10-30
catalystActivity[CatalystActivity:9029144] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643864] protein tyrosine kinase activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane] Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9027378] May, Bruce, 2017-11-01
edited[InstanceEdit:9027411] May, Bruce, 2017-10-30
inferredFrom
input[Complex:9027402] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PLCG1,2 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9027367] Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line
modified[InstanceEdit:9029175] May, Bruce, 2017-11-14
[InstanceEdit:9031741] May, Bruce, 2017-12-02
[InstanceEdit:9616794] Matthews, Lisa, 2018-08-14
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameLYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2
output[Complex:9029094] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2018-09-12
reviewed[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9027439] R-HSA-9027425.3
summation[Summation:9031739] PLCG1 (Phospholipase C gamma1) or PLCG2 bound to the activat...
(hasEvent)[Pathway:9027277] Erythropoietin activates Phospholipase C gamma (PLCG) [Homo sapiens]
(precedingEvent)[Reaction:9032478] EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate [Homo sapiens]
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No pathways have been reviewed or authored by LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2 (9027425)
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