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Details on Person CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA

Class:Id	Reaction:9027302
_displayName	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA
_doRelease	TRUE
_timestamp	2018-02-21 13:56:28
authored	[InstanceEdit:9027299] Jassal, Bijay, 2017-10-30
catalystActivity	[CatalystActivity:9028883] monooxygenase activity of CYP2E1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9027299] Jassal, Bijay, 2017-10-30
edited	[InstanceEdit:9027299] Jassal, Bijay, 2017-10-30
input	[SimpleEntity:9027029] 14(S)-HDHA [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9027325] Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing [LiteratureReference:9027314] 14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds [LiteratureReference:9027023] Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions
modified	[InstanceEdit:9027336] Jassal, Bijay, 2017-10-30 [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 [InstanceEdit:9037605] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037805] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA
output	[DefinedSet:9027326] 14(S),21(S/R)-diHDHA [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:9027033] Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA [Homo sapiens] [Reaction:9020274] ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9027331] R-HSA-9027302.2
summation	[Summation:9027318] In macrophages, cytochrome P450s (CYPs) are likely to 21-hyd...
(hasEvent)	[Pathway:9027307] Biosynthesis of maresin-like SPMs [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9031803] Maresin-like SPMs translocate from cytosol to extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA (9027302)