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Details on Person After Stat5 binds the Epo:Epor complex, phosphorylated Jak2 ...
| Class:Id | Summation:9027269 |
|---|---|
| _displayName | After Stat5 binds the Epo:Epor complex, phosphorylated Jak2 ... |
| _timestamp | 2018-01-27 04:31:06 |
| created | [InstanceEdit:9027279] May, Bruce, 2017-10-29 |
| modified | [InstanceEdit:9030341] May, Bruce, 2017-11-27 [InstanceEdit:9036005] May, Bruce, 2018-01-27 |
| text | After Stat5 binds the Epo:Epor complex, phosphorylated Jak2 and Lyn phosphorylate Stat5 (Stat5a or Stat5b) (Damen et al. 1995, Paillard et al. 1995, Penta and Sawyer 1995, Wakao et al. 1995, Klingmuller et al. 1996, Quelle et al. 1996, Tilbrook et al. 1996, Iwatsuki et al. 1997, Yamamura et al. 1998, Ilaria et al. 1999, Zochodne et al. 2000). Deletion of Stat5a and Stat5b produced somewhat contradictory results: Teglund et al. (1998) found no effect on Epo functions, indicating that activation of Stat5 may be redundant with other signaling pathways, while Socolovsky et al. (2001) found ineffective erythropoiesis. |
| (summation) | [Reaction:9012653] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5 [Mus musculus] |
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