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Details on Person Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k

Class:Id	Reaction:9027268
_displayName	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k
_doRelease	TRUE
_timestamp	2018-08-14 15:49:30
authored	[InstanceEdit:9027270] May, Bruce, 2017-10-21
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9027279] May, Bruce, 2017-10-29
edited	[InstanceEdit:9027270] May, Bruce, 2017-10-21
input	[Complex:9006303] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 [plasma membrane] [Mus musculus] [DefinedSet:9027243] Pi3k alpha, gamma [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:9027152] Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors [LiteratureReference:9030307] Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor [LiteratureReference:9030309] Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity [LiteratureReference:9030317] Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain [LiteratureReference:9030305] Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor
modified	[InstanceEdit:9027444] May, Bruce, 2017-11-01 [InstanceEdit:9030341] May, Bruce, 2017-11-27 [InstanceEdit:9616794] Matthews, Lisa, 2018-08-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k
output	[Complex:9027233] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Pi3k [plasma membrane] [Mus musculus]
releaseDate	2018-09-12
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9027286] R-MMU-9027268.2
summation	[Summation:9030321] Phosphatidylinositol 4,5-bisphosphate 3-kinase (Pi3k) direct...
(inferredFrom)	[Reaction:9027280] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K [Homo sapiens]
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No pathways have been reviewed or authored by Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k (9027268)