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Details on Person NTRK2 activates RAS signaling through SHC1

Class:Id	Reaction:9026891
_displayName	NTRK2 activates RAS signaling through SHC1
_doRelease	TRUE
_timestamp	2024-03-18 20:29:21
authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9028331] guanyl-nucleotide exchange factor activity of BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9026892] Orlic-Milacic, Marija, 2017-10-24
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
inferredFrom	[Reaction:9030763] Ntrk2 activates Ras signaling through Shc1 [Rattus norvegicus]
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:9028345] Orlic-Milacic, Marija, 2017-11-07 [InstanceEdit:9030768] Orlic-Milacic, Marija, 2017-11-28 [InstanceEdit:9037702] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9037704] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9037712] Orlic-Milacic, Marija, 2018-02-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865786] Orlic-Milacic, Marija, 2024-03-18
name	NTRK2 activates RAS signaling through SHC1
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:9026890] NTRK2 phosphorylates SHC1 [Homo sapiens] [Reaction:9026493] p-Y516 of p-5Y-NTRK2 recruits SHC1 [Homo sapiens] [Reaction:9028328] SHC1 bound to activated NTRK2 recruits GRB2:SOS1 [Homo sapiens] [Reaction:9026890] NTRK2 phosphorylates SHC1 [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9026895] R-HSA-9026891.3
summation	[Summation:9028338] SHC1-mediated recruitment of GRB2:SOS1 to the activated NTRK...
(hasEvent)	[Pathway:9026519] Activated NTRK2 signals through RAS [Homo sapiens]
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No pathways have been reviewed or authored by NTRK2 activates RAS signaling through SHC1 (9026891)