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Details on Person GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

Class:Id	Reaction:9026777
_displayName	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1
_doRelease	TRUE
_timestamp	2024-07-25 23:01:56
authored	[InstanceEdit:9026773] Jassal, Bijay, 2017-10-23
catalystActivity	[CatalystActivity:9026765] glutathione transferase activity of GSTM4 dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9026773] Jassal, Bijay, 2017-10-23
crossReference	[DatabaseIdentifier:9916774] RHEA:53509
edited	[InstanceEdit:9026773] Jassal, Bijay, 2017-10-23
input	[SimpleEntity:9025001] 13(S),14(S)-epoxy-DHA [cytosol] [SimpleEntity:29450] GSH [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9026774] Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages [LiteratureReference:9026754] Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection [LiteratureReference:9026923] Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3
modified	[InstanceEdit:9026928] Jassal, Bijay, 2017-10-24 [InstanceEdit:9028878] Jassal, Bijay, 2017-11-13 [InstanceEdit:9037606] Jassal, Bijay, 2018-02-20 [InstanceEdit:9037808] Jassal, Bijay, 2018-02-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9916754] D'Eustachio, Peter, 2024-07-25
name	GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione => (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate
output	[SimpleEntity:9026761] MCTR1 [cytosol]
precedingEvent	[Reaction:9024983] ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA [Homo sapiens] [Reaction:9020274] ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA [Homo sapiens]
releaseDate	2018-03-21
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9026786] R-HSA-9026777.3
summation	[Summation:9026759] Cytosolic, dimeric glutathione S-transferase Mu 4 (GSTM4 dim...
(hasEvent)	[Pathway:9026762] Biosynthesis of maresin conjugates in tissue regeneration (MCTR) [Homo sapiens]
(precedingEvent)	[Reaction:9026757] GGT hydrolyses MCTR1 to MCTR2 [Homo sapiens] [BlackBoxEvent:9031856] Sulfido conjugates translocate from cytosol to extracellular region [Homo sapiens]
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No pathways have been reviewed or authored by GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1 (9026777)