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Details on Person DPEP hydrolyses MCTR2 to MCTR3

Class:IdReaction:9026771
_displayNameDPEP hydrolyses MCTR2 to MCTR3
_doReleaseTRUE
_timestamp2024-07-25 23:01:52
authored[InstanceEdit:9026773] Jassal, Bijay, 2017-10-23
catalystActivity[CatalystActivity:9026769] dipeptidase activity of DPEP [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9026773] Jassal, Bijay, 2017-10-23
crossReference[DatabaseIdentifier:9916749] RHEA:53541
edited[InstanceEdit:9026773] Jassal, Bijay, 2017-10-23
input[SimpleEntity:9026760] MCTR2 [cytosol]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9026754] Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection
[LiteratureReference:9026774] Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages
[LiteratureReference:9026923] Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3
modified[InstanceEdit:9026928] Jassal, Bijay, 2017-10-24
[InstanceEdit:9028878] Jassal, Bijay, 2017-11-13
[InstanceEdit:9037606] Jassal, Bijay, 2018-02-20
[InstanceEdit:9037805] Jassal, Bijay, 2018-02-21
[InstanceEdit:9663465] D'Eustachio, Peter, 2019-10-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9916754] D'Eustachio, Peter, 2024-07-25
nameDPEP hydrolyses MCTR2 to MCTR3
(13R)-S-cysteinylglycyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + H2O => (13R)-S-cysteinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glycine
output[SimpleEntity:9026776] MCTR3 [cytosol]
[SimpleEntity:29424] Gly [cytosol]
precedingEvent
releaseDate2018-03-21
reviewed[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9026784] R-HSA-9026771.4
summation[Summation:9026752] In human macrophages, a dipeptidase (DPEP) is proposed to hy...
(hasEvent)[Pathway:9026762] Biosynthesis of maresin conjugates in tissue regeneration (MCTR) [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9031856] Sulfido conjugates translocate from cytosol to extracellular region [Homo sapiens]
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