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Details on Person In human macrophages, a dipeptidase (DPEP) is proposed to hy...
| Class:Id | Summation:9026752 |
|---|---|
| _displayName | In human macrophages, a dipeptidase (DPEP) is proposed to hy... |
| _timestamp | 2017-10-24 14:10:29 |
| created | [InstanceEdit:9026773] Jassal, Bijay, 2017-10-23 |
| modified | [InstanceEdit:9026928] Jassal, Bijay, 2017-10-24 |
| text | In human macrophages, a dipeptidase (DPEP) is proposed to hydrolyse maresin conjugates in tissue regeneration 2 (MCTR2) to MCTR3, identified as 13(R)-cysteinyl, 14(S)-hydroxy-4Z,7Z,9E,11E,13R,14S,16Z,19Zdocosahexaenoic acid (Dalli et al. 2014, 2016a, 2016b). Incubation of human macrophages with MCTR2 and a DPEP inhibitor demonstrates significantly higher MCTR2 levels and significantly lower MCTR3 levels, suggesting a DPEP mediates MCTR2 hydrolysis (Dalli et al. 2016a). MCTR3 displays potent activity in proresolution of inflammation and tissue regeneration (Dalli et al. 2016b). |
| (summation) | [Reaction:9026771] DPEP hydrolyses MCTR2 to MCTR3 [Homo sapiens] |
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No pathways have been reviewed or authored by In human macrophages, a dipeptidase (DPEP) is proposed to hy... (9026752)
