Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Autophosphorylated tyrosine Y516 of NTRK2 (corresponds to Y5...

Class:IdSummation:9026490
_displayNameAutophosphorylated tyrosine Y516 of NTRK2 (corresponds to Y5...
_timestamp2017-12-21 16:58:16
created[InstanceEdit:9026489] Orlic-Milacic, Marija, 2017-10-19
literatureReference[LiteratureReference:9026591] Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction
[LiteratureReference:9026468] The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL
[LiteratureReference:9026486] Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses
[LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events
modified[InstanceEdit:9026525] Orlic-Milacic, Marija, 2017-10-19
[InstanceEdit:9026589] Orlic-Milacic, Marija, 2017-10-20
[InstanceEdit:9026592] Orlic-Milacic, Marija, 2017-10-20
[InstanceEdit:9026811] Orlic-Milacic, Marija, 2017-10-23
[InstanceEdit:9026812] Orlic-Milacic, Marija, 2017-10-23
[InstanceEdit:9033456] Orlic-Milacic, Marija, 2017-12-21
textAutophosphorylated tyrosine Y516 of NTRK2 (corresponds to Y515 of the full-length mouse Ntrk2 and Y484 of the mature rat Ntrk2) is a docking site for SHC1 isoforms p52 (SHC1-2) and p46 (SHC1-3), which function as activators of RAS signaling (Minichiello et al. 1998, McCarthy and Feinstein 1998, McCarthy and Feinstein 1999). SHC1 is recruited to Y516 of NTRK2 in response to BDNF stimulation (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999) and NTF4 stimulation (Minichiello et al. 1998, Yuen and Mobley 1999). Recruitment of SHC1 to NTRK2 in response to stimulation by NTF3 has not been examined.
(summation)[Reaction:9026493] p-Y516 of p-5Y-NTRK2 recruits SHC1 [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Autophosphorylated tyrosine Y516 of NTRK2 (corresponds to Y5... (9026490)
Follow Reactome