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Details on Person BDNF-induced dimerization of the receptor tyrosine kinase NT...
| Class:Id | Summation:9026470 |
|---|---|
| _displayName | BDNF-induced dimerization of the receptor tyrosine kinase NT... |
| _timestamp | 2017-11-27 13:46:50 |
| created | [InstanceEdit:9026467] Orlic-Milacic, Marija, 2017-10-19 |
| literatureReference | [LiteratureReference:9026468] The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL [LiteratureReference:9026486] Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses [LiteratureReference:9026585] Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis |
| modified | [InstanceEdit:9026488] Orlic-Milacic, Marija, 2017-10-19 [InstanceEdit:9026588] Orlic-Milacic, Marija, 2017-10-20 [InstanceEdit:9030381] Orlic-Milacic, Marija, 2017-11-27 |
| text | BDNF-induced dimerization of the receptor tyrosine kinase NTRK2 (TRKB) leads to trans-autophosphorylation of NTRK2 on five evolutionarily conserved tyrosine residues in the cytoplasmic tail of NTRK2: Y516, Y702, Y706, Y707 and Y817. Phosphorylation at Y516, Y702, Y706, Y707 and Y817 was demonstrated by using a recombinant human BDNF and a recombinant rat Ntrk2. Tyrosine residues Y516, Y702, Y706, Y707 and Y817 of full-length human NTRK2 correspond to Y484, Y670, Y674, Y675 and Y785 of mature rat Ntrk2 (Y515, Y701, Y705, Y706 and Y816 of full-length rat Ntrk2), respectively (Guiton et al. 1994, McCarty and Feinstein 1999). Human NTRK2 residue Y516 corresponds to mouse Ntrk2 residue Y515, which was also shown to be phosphorylated in response to BDNF stimulation (Minichiello et al. 1998). |
| (summation) | [Reaction:9026464] BDNF-bound NTRK2 dimers trans-autophosphorylate [Homo sapiens] |
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