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Details on Person The neurotrophic factor NTF4 (neurotrophin-4), which functio...

Class:IdSummation:9026444
_displayNameThe neurotrophic factor NTF4 (neurotrophin-4), which functio...
_timestamp2017-10-19 16:26:44
created[InstanceEdit:9026443] Orlic-Milacic, Marija, 2017-10-19
literatureReference[LiteratureReference:9025077] The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site
[LiteratureReference:9025040] TrkB dimerization during development of the prefrontal cortex of the macaque
[LiteratureReference:9026442] The trkB tyrosine protein kinase is a receptor for neurotrophin-4
[LiteratureReference:9026441] Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF
textThe neurotrophic factor NTF4 (neurotrophin-4), which functions as a homodimer (Robinson et al. 1999), is a ligand for the neurotrophin receptor tyrosine kinase NTRK2 (TRKB) (Klein et al. 1992, Ip et al. 1993, Ohira et al. 2001).
(summation)[Reaction:9026358] NTF4 binds NTRK2 [Homo sapiens]
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